B6Ola.Cg-Gpi1^a Tyr^c/Gpi1^c Tyr^c/WsH

Status	Available to order
EMMA ID	EM:02608
Citation information	RRID:IMSR_EM:02608 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Ola.Cg-Gpi1^a Tyr^c/Gpi1^c Tyr^c/WsH
Alternative name	C57BL/Ola-Gpi1-s^c,c/Ws
Strain type	Other
Allele/Transgene symbol	Gpi1^c, Tyr^c, Gpi1^a
Gene/Transgene symbol	Gpi1, Tyr, Gpi1

Information from provider

Provider	John West
Provider affiliation	Genes and Development Group, University of Edinburgh
Genetic information	Unpigmented and electrophoretic variant. Produced by intercrossing C57BL/Ola-Gpi1-s^c/Ws and C57BL/Ola.AKR-Gpi1-s^a Tyr^c/Ws.
Phenotypic information	Unpigmented (albino) and electrophoretic variant of Gpi1-s^c.
Breeding history	Produced by intercrossing C57BL/Ola-Gpi1-s^c/Ws and C57BL/Ola.AKR-Gpi1-s^a Tyr^c/Ws. Now congenic on C57BL/6Ola. Archived material is heterozygous: Gpi1-s^b/c, Gpi1-s^c.
References	Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus).;DeLorenzo R J, Ruddle F H, ;1969;Biochemical genetics;3;151-62; 5364923 Genetic differences in glucose phosphate isomerase activity among mouse embryos.;West J D, Flockhart J H, ;1989;Development (Cambridge, England);107;465-72; 2612373
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Temperature-sensitive oculocutaneous albinism type 1 / Orphanet_352737
Oculocutaneous albinism type 1A / Orphanet_79431
Oculocutaneous albinism type 1B / Orphanet_79434
Minimal pigment oculocutaneous albinism type 1 / Orphanet_352734
Ocular albinism with congenital sensorineural deafness / Orphanet_352740

MGI phenotypes (allele matching)

absent coat pigmentation / MGI
diluted coat color / MGI
abnormal coat/hair pigmentation / MGI
absent eye pigmentation / MGI
abnormal coat appearance / MGI
decreased eye pigmentation / MGI
mottled coat / MGI
abnormal eye pigmentation / MGI
belly spot / MGI
hypopigmentation / MGI
variegated eye pigmentation pattern / MGI
decreased ear pigmentation / MGI

MGI phenotypes (gene matching)

decreased hematocrit / MGI
decreased body weight / MGI
prenatal lethality / MGI
abnormal embryonic tissue morphology / MGI
abnormal erythrocyte morphology / MGI
increased mean corpuscular volume / MGI
reticulocytosis / MGI
increased heart weight / MGI
decreased erythrocyte cell number / MGI
increased liver weight / MGI
abnormal erythrocyte physiology / MGI
abnormal erythrocyte osmotic lysis / MGI
increased spleen weight / MGI
increased circulating bilirubin level / MGI
increased circulating glucose level / MGI
decreased mean corpuscular hemoglobin / MGI
abnormal enzyme/coenzyme activity / MGI
increased lung weight / MGI
decreased mean corpuscular hemoglobin concentration / MGI
lethality, incomplete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality between implantation and placentation, complete penetrance / MGI
preweaning lethality, complete penetrance / MGI
abnormal cell morphology / MGI
diluted coat color / MGI
irregular coat pigmentation / MGI
belly spot / MGI
absent hair follicle melanin granules / MGI
shiny fur / MGI
mottled coat / MGI
abnormal retinal photoreceptor morphology / MGI
pigmentation phenotype / MGI
absent skin pigmentation / MGI
abnormal keratinocyte apoptosis / MGI
abnormal eye pigmentation / MGI
abnormal retina morphology / MGI
retinal degeneration / MGI
decreased retinal photoreceptor cell number / MGI
abnormal coat appearance / MGI
male infertility / MGI
abnormal coat/hair pigmentation / MGI
prenatal lethality / MGI
premature death / MGI
abnormal vision / MGI
abnormal skin pigmentation / MGI
no abnormal phenotype detected / MGI
no phenotypic analysis / MGI
abnormal cell nucleus morphology / MGI
failure of zygotic cell division / MGI
single kidney / MGI
absent seminal vesicle / MGI
abnormal chromosome morphology / MGI
chromosome breakage / MGI
induced chromosome breakage / MGI
increased cellular sensitivity to ionizing radiation / MGI
abnormal miscarriage rate / MGI
abnormal hair follicle melanogenesis / MGI
abnormal melanosome morphology / MGI
abnormal iris pigmentation / MGI
absent coat pigmentation / MGI
decreased eye pigmentation / MGI
abnormal aqueous drainage system morphology / MGI
abnormal retinal ganglion layer morphology / MGI
abnormal eye physiology / MGI
abnormal intraocular pressure / MGI
variegated coat color / MGI
homeostasis/metabolism phenotype / MGI
reproductive system phenotype / MGI
vision/eye phenotype / MGI
hypopigmentation / MGI
ocular albinism / MGI
absent eye pigmentation / MGI
decreased survivor rate / MGI
transverse fur striping / MGI
mortality/aging / MGI
abnormal survival / MGI
integument phenotype / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, complete penetrance / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality at implantation, complete penetrance / MGI
embryonic lethality before implantation, complete penetrance / MGI
decreased ear pigmentation / MGI
variegated eye pigmentation pattern / MGI
decreased a wave amplitude / MGI
decreased b wave amplitude / MGI

Literature references

Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus).;DeLorenzo R J, Ruddle F H, ;1969;Biochemical genetics;3;151-62; 5364923
Genetic differences in glucose phosphate isomerase activity among mouse embryos.;West J D, Flockhart J H, ;1989;Development (Cambridge, England);107;465-72; 2612373

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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B6Ola.Cg-Gpi1a Tyrc/Gpi1c Tyrc/WsH