| Status | Available to order |
| EMMA ID | EM:02610 |
| Citation information | RRID:IMSR_EM:02610 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CnbcHsdWin:NMRI-Tg(Tyr-Th,-Gch1)6775Lmon |
| Alternative name | TyrTH |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tyr-Th,-Gch1)6775Lmon, Tyrc |
| Gene/Transgene symbol | Tg(Tyr-Th,-Gch1)6775Lmon, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Genetic information | Transgenic mice carrying a chimeric functional tyrosine hydroxylase (Th) minigene and GTP-cyclohydrolase 1 (Gch1 or GTP-Ch1) cDNA under the control of mouse tyrosinase (Tyr) promoter and LCR elements. Animal mouse model of oculocutaneous albinism type 1 (OCA1). |
| Phenotypic information | Externally, undistinguishable from a common albino phenotype. However, internally, visual acuity, chiasmatic projections and retina development have been corrected due to the presence of the TyrTH transgenic construct. |
| Breeding history | Transgenic mice were generated in HsdWin:NMRI albino outbred mice and have been maintained since then in hemizygous state by breeding with the same strain. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous NMRI males, wild-type NMRI females |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
