B6J.SEG-(D19Mit85-D19Mit80)/Cnbc

Status	Available to order
EMMA ID	EM:02613
Citation information	RRID:IMSR_EM:02613 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6J.SEG-(D19Mit85-D19Mit80)/Cnbc
Alternative name	NRH-1
Strain type	Spontaneous
Allele/Transgene symbol	Anxa1, Tlyr1
Gene/Transgene symbol	Anxa1, Tlyr1

Information from provider

Provider	Javier Santos
Provider affiliation	Cellular Biology and Immunology, Centro de Biologia Molecular Severo Ochoa (CBMSO-UAM/CSIC)
Genetic information	Congenic mouse strain carrying a SEG/Pas chromosome 19 segment, defined between D19Mit85 and D19Mit80 markers, into C57BL/6J. These mice originate from interspecific recombinant congenic strain (IRCS) 6A, generated at Institut Pasteur (Paris, France).
Phenotypic information	Mice carrying this mutation show a higher resistance to gamma-irradiation induced thymic lymphoma (Tlyr1) incidence, as compared to C57BL/6J background mice.
Breeding history	From the IRCS 6A strain the animals were backcrossed to C57BL/6J, and the selected congenic mice have been maintained in this inbred strain since then.
References	A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice.;Santos Javier, Montagutelli Xavier, Acevedo Abraham, López Pilar, Vaquero Concepción, Fernández Mónica, Arnau Maria-Rosa, Szatanik Marek, Salido Eduardo, Guénet Jean-Louis, Fernández-Piqueras José, ;2002;Oncogene;21;6680-3; 12242666
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos	8-cell

Disease and phenotype information

IMPC phenotypes (gene matching)

small spleen / IMPC
enlarged epididymis / IMPC
enlarged thymus / IMPC
increased circulating alanine transaminase level / IMPC
increased airway resistance / IMPC
enlarged heart / IMPC
abnormal auditory brainstem response / IMPC
enlarged spleen / IMPC
abnormal heart morphology / IMPC
enlarged uterus / IMPC
abnormal thymus morphology / IMPC
abnormal spleen morphology / IMPC
increased spleen weight / IMPC
small kidney / IMPC
abnormal uterus morphology / IMPC
decreased circulating iron level / IMPC
abnormal epididymis morphology / IMPC

Literature references

A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice.;Santos Javier, Montagutelli Xavier, Acevedo Abraham, López Pilar, Vaquero Concepción, Fernández Mónica, Arnau Maria-Rosa, Szatanik Marek, Salido Eduardo, Guénet Jean-Louis, Fernández-Piqueras José, ;2002;Oncogene;21;6680-3; 12242666

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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