| Status | Available to order |
| EMMA ID | EM:03105 |
| Citation information | RRID:IMSR_EM:03105 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Cnbc:NMRI-Tg(Tyr*)4794Lmon |
| Alternative name | YRT2deltaLCR |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tyr*)4794Lmon, Tyrc |
| Gene/Transgene symbol | Tg(Tyr*)4794Lmon, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Genetic information | Transgenic mice carrying 1 copy of the 250 kb YAC YRT2deltaLCR derived from YAC YRT2 after removing the LCR element by homologous recombination of YRT2 YAC (Montoliu et al. 1996; EMBO J 15:6026-34). Mice were generated in the albino outbred CD1 background by ICSI-mediated metaphase II oocytes transgenesis, whose albino phenotype was partially rescued by the YAC YRT2deltaLCR transgene, thereby becoming very lightly pigmented (almost albino coat colour) with obvious eye pigmentation. The YAC YRT2deltaLCR is derived from a YAC library made from C3H mouse genomic DNA. The founder mouse (in CD1 mouse background) was backcrossed to albino outbred NMRI (more than 10 generations) and has been maintained in NMRI background since then. |
| Phenotypic information | Very light coat colour, almost albino, black eyes. Transgenic mice YRT2deltaLCR in the NMRI background have pigmented eyes and very light skin pigmentation (almost albino). |
| Breeding history | Transgenic mice YRT2deltaLCR were generated by ICSI-mediated metaphase II oocyte transgenesis in CD1 outbred albino mice. The founder mouse was backcrosses to NMRI for more than 10 generations and have been maintained as hemizygous since then in the same albino outbred NMRI background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous NMRI males, wild-type NMRI females |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
