| Status | Available to order |
| EMMA ID | EM:03109 |
| Citation information | RRID:IMSR_EM:03109 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Cnbc:NMRI-Tg(Tyr*)8749Lmon |
| Alternative name | YRT2deltaAB line 8749 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tyr*)8749Lmon, Tyrc |
| Gene/Transgene symbol | Tg(Tyr*)8749Lmon, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Genetic information | Transgenic mice carrying 1 copy of the 250 kb YAC YRT2deltaAB derived from YAC YRT2 after removing box A and box B elements (Giraldo et al. Nucleic Acids Res. 2003; 31, 6290-6305), by homologous recombination of YRT2 YAC (Montoliu et al. 1996; EMBO J 15:6026-34). Mice were generated in the albino outbred WinHsd:NMRI background whose albino phenotype was partially rescued by the YAC YRT2deltaAB transgene, thereby becoming pigmented (dark grey, no variegation observed) and eye pigmented. The YAC YRT2deltaAB is derived from a YAC library made from C3H mouse genomic DNA. |
| Phenotypic information | Dark grey, uniform, black eyes. Transgenic mice YRT2deltaAB in the NMRI background have pigmented eyes and dark grey skin pigmentation, with no variegation observed in coat and retina. |
| Breeding history | Transgenic mice YRT2deltaAB were generated by pronuclear microinjection using fertilised albino outbred NMRI oocytes and have been maintained as hemizygous since then in the same background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous NMRI males, wild-type NMRI females |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
