IMPC phenotypes (gene matching)
- abnormal auditory brainstem response / IMPC
B6;129-Reg2tm1Lchr/H
| Status | Available to order |
| EMMA ID | EM:03572 |
| Citation information | RRID:IMSR_EM:03572 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Reg2tm1Lchr/H |
| Alternative name | RegIIIbeta knock out/C57BL6x129SV |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Reg2tm1Lchr |
| Gene/Transgene symbol | Reg2 |
Information from provider
| Provider | SP Hunt |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Additional owner | Andrew Smith, University of Edinburgh, Institute for Stem Cell Research, Gene Targeting Lab, Edinburgh, Scotland UK |
| Genetic information | Targeting construct for Reg2 (RegIII beta) gene locus is derived from 129 DNA. A region of sequence from a position within exon 2 extending to a position in exon 5 was replaced by the reporter/selection cassette IRES-Tau-LacZ/loxP/MC1neopA/loxP, thus deleting entirely exons 3 and 4. |
| Phenotypic information | Deletion of Reg2 (RegIII beta) gene. Viable, normal breeding pattern, no obvious phenotype. |
| Breeding history | Inbred for 20 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous inbred males |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal hypoglossal nerve morphology / MGI
- abnormal suckling behavior / MGI
- nervous system phenotype / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- decreased hepatocyte proliferation / MGI
- increased susceptibility to injury / MGI
- decreased liver regeneration / MGI
- increased cellular sensitivity to oxidative stress / MGI
- increased sensitivity to induced morbidity/mortality / MGI
MGI phenotypes (gene matching)
- abnormal hypoglossal nerve morphology / MGI
- abnormal suckling behavior / MGI
- nervous system phenotype / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- decreased hepatocyte proliferation / MGI
- increased susceptibility to injury / MGI
- decreased liver regeneration / MGI
- increased cellular sensitivity to oxidative stress / MGI
- increased sensitivity to induced morbidity/mortality / MGI
Literature references
- Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.;Lieu Hanh-Tu, Simon Marie-Thérèse, Nguyen-Khoa Thao, Kebede Messeret, Cortes Alexandre, Tebar Luis, Smith Andrew J H, Bayne Rosemary, Hunt Stephen P, Bréchot Christian, Christa Laurence, ;2006;Hepatology (Baltimore, Md.);44;1452-64; 17133485