C3H.C-Trpc3^Mwk/H

Status	Available to order
EMMA ID	EM:00431
Citation information	RRID:IMSR_EM:00431 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C3H.C-Trpc3^Mwk/H
Alternative name	BHV7
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Trpc3^Mwk
Gene/Transgene symbol	Trpc3

Information from provider

Provider	Pat Nolan
Provider affiliation	MRC Mammalian Genetics Unit
Genetic information	ENU-induced point mutation in exon 7: an A-to-G nucleotide change at position 1903. This causes a threonine-to-alanine amino acid change at residue 635 in the highly conserved S4/S5 linker region.
Phenotypic information	Mice heterozygous for this mutation are usually small and exhibit a staggering phenotype. These ataxic mice have limited movement in their back legs. Homozygotes have not been tested.
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Spinocerebellar ataxia type 41 / Orphanet_458798

IMPC phenotypes (allele matching)

decreased bone mineral density / IMPC
abnormal forelimb morphology / IMPC
abnormal gait / IMPC
abnormal response to new environment / IMPC
increased startle reflex / IMPC
limb grasping / IMPC
increased mean corpuscular volume / IMPC
abnormal bone mineralization / IMPC
abnormal locomotor activation / IMPC
increased lean body mass / IMPC
decreased lean body mass / IMPC
corneal vascularization / IMPC
decreased circulating amylase level / IMPC
increased circulating iron level / IMPC
increased total body fat amount / IMPC
increased bone mineral content / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

decreased circulating amylase level / IMPC
decreased lean body mass / IMPC
increased circulating iron level / IMPC
abnormal gait / IMPC
abnormal locomotor activation / IMPC
increased lean body mass / IMPC
abnormal bone mineralization / IMPC
corneal vascularization / IMPC
increased bone mineral content / IMPC
increased total body fat amount / IMPC
decreased bone mineral density / IMPC
limb grasping / IMPC
increased startle reflex / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal response to new environment / IMPC
increased mean corpuscular volume / IMPC
abnormal forelimb morphology / IMPC

MGI phenotypes (allele matching)

abnormal Purkinje cell morphology / MGI
decreased Purkinje cell number / MGI
decreased body size / MGI
abnormal gait / MGI
impaired balance / MGI
abnormal nervous system electrophysiology / MGI
abnormal Purkinje cell dendrite morphology / MGI
premature death / MGI

MGI phenotypes (gene matching)

abnormal Purkinje cell morphology / MGI
decreased Purkinje cell number / MGI
decreased body size / MGI
abnormal gait / MGI
impaired limb coordination / MGI
impaired balance / MGI
premature death / MGI
abnormal nervous system electrophysiology / MGI
abnormal excitatory postsynaptic currents / MGI
nervous system phenotype / MGI
abnormal eye physiology / MGI
immune system phenotype / MGI
hematopoietic system phenotype / MGI
abnormal Purkinje cell dendrite morphology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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C3H.C-Trpc3Mwk/H