IMPC phenotypes (gene matching)
- increased circulating alanine transaminase level / IMPC
B6;129-Il23rtm1Kuv/Orl
| Status | Available to order |
| EMMA ID | EM:04315 |
| Citation information | RRID:IMSR_EM:04315 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Il23rtm1Kuv/Orl |
| Alternative name | B6.129Sv/Pas-Il23rtm |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Il23rtm1Kuv |
| Gene/Transgene symbol | Il23r |
Information from provider
| Provider | Philip ROSENSTIEL |
| Provider affiliation | IKMB, University of Kiel |
| Genetic information | Conditional deletion of the exon 4 (124 bp) by insertion of two loxP sites, resulting in an out-of-frame splice. Details available upon request. |
| Phenotypic information | Not known. |
| Breeding history | Backcrossed to C57BL/6 for less than 5 generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- immune system phenotype / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- abnormal CD4-positive T cell differentiation / MGI
- decreased susceptibility to induced colitis / MGI
- abnormal circulating interleukin level / MGI
- increased circulating interleukin-17 level / MGI
- decreased interleukin-9 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI