B6.CAnNCrl(C3H)-Dync1li1^m1Emcf/H

Status	Available to order
EMMA ID	EM:04327
Citation information	RRID:IMSR_EM:04327 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.CAnNCrl(C3H)-Dync1li1^m1Emcf/H
Alternative name	Dync1li N235Y Cytoplasmic dynein light intermediate chain 1 N235Y mutation
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Dync1li1^m1Emcf
Gene/Transgene symbol	Dync1li1

Information from provider

Provider	Elizabeth Fisher
Provider affiliation	Neurodegenerative Disease, UCL Institute of Neurology
Additional owner	This mutant originally came from the Harwell- GSK ENU mutagenesis screen, number EMRCD/12.2b.
Genetic information	Carries and ENU induced point mutation in exon 5, a A to T change at bp 754 causing an asparagine to tyrosine change at residue 235.
Phenotypic information	Mouse not completely assessed but so far homozygotes have behavioural and neurological changes.
Breeding history	Mouse was sent from the ENU program at Harwell, thus first generation were (C3H/HeH x BALB/cAnN)F1. Backcrossed to C57BL/6J from then on. Mice submitted are at N6 backcrossed to C57BL/6J.
References	Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.;Banks Gareth T, Haas Matilda A, Line Samantha, Shepherd Hazel L, Alqatari Mona, Stewart Sammy, Rishal Ida, Philpott Amelia, Kalmar Bernadett, Kuta Anna, Groves Michael, Parkinson Nicholas, Acevedo-Arozena Abraham, Brandner Sebastian, Bannerman David, Greensmith Linda, Hafezparast Majid, Koltzenburg Martin, Deacon Robert, Fainzilber Mike, Fisher Elizabeth M C, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;5483-94; 21471385
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	homozygous C57BL/6J males
Breeding at archiving centre	No breeding was performed at the archiving centre. Imported males were believed to be homozygous, backcross 6 to C57BL/6J.

Disease and phenotype information

IMPC phenotypes (gene matching)

hypoplasia / IMPC
mydriasis / IMPC
preweaning lethality, incomplete penetrance / IMPC
abnormal sternum morphology / IMPC
small heart / IMPC
abnormal lung morphology / IMPC
microphthalmia / IMPC
abnormal testis morphology / IMPC
abnormal seminal vesicle morphology / IMPC
enlarged lymph nodes / IMPC
small kidney / IMPC
abnormal skin morphology / IMPC
enlarged prostate gland / IMPC
increased red blood cell distribution width / IMPC
abnormal liver morphology / IMPC

MGI phenotypes (allele matching)

increased anxiety-related response / MGI
abnormal gait / MGI
decreased exploration in new environment / MGI
abnormal lysosome physiology / MGI
nervous system phenotype / MGI
increased defecation amount / MGI
behavior/neurological phenotype / MGI
abnormal action potential / MGI
abnormal neuronal migration / MGI
abnormal dendrite morphology / MGI
increased grip strength / MGI

MGI phenotypes (gene matching)

increased anxiety-related response / MGI
abnormal gait / MGI
decreased exploration in new environment / MGI
abnormal lysosome physiology / MGI
nervous system phenotype / MGI
increased defecation amount / MGI
behavior/neurological phenotype / MGI
abnormal action potential / MGI
abnormal neuronal migration / MGI
abnormal dendrite morphology / MGI
increased grip strength / MGI

Literature references

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.;Banks Gareth T, Haas Matilda A, Line Samantha, Shepherd Hazel L, Alqatari Mona, Stewart Sammy, Rishal Ida, Philpott Amelia, Kalmar Bernadett, Kuta Anna, Groves Michael, Parkinson Nicholas, Acevedo-Arozena Abraham, Brandner Sebastian, Bannerman David, Greensmith Linda, Hafezparast Majid, Koltzenburg Martin, Deacon Robert, Fainzilber Mike, Fisher Elizabeth M C, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;5483-94; 21471385

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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B6.CAnNCrl(C3H)-Dync1li1m1Emcf/H