MGI phenotypes (allele matching)
B6.129P2(Cg)-Tlx1tm1Thr/H
| Status | Available to order |
| EMMA ID | EM:04332 |
| Citation information | RRID:IMSR_EM:04332 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2(Cg)-Tlx1tm1Thr/H |
| Alternative name | Tlx1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tlx1tm1Thr |
| Gene/Transgene symbol | Tlx1 |
Information from provider
| Provider | Terence Rabbitts |
| Provider affiliation | Leeds Institute of Molecular Medicine, St James |
| Genetic information | lacZ expressed in all cells that normally express Tlx1 (Hox11), e.g. splenic mesenchyme, auditory meatus. |
| Phenotypic information | Asplenia. |
| Breeding history | Inbred as heterozygotes. Chimaeric mice were bred with MF1 animals and subsequently backcrossed to C57BL/6JI (Max-Planck Institute of Immunobiology substrain). At N10 they were intercrossed. The C57BL/6JI nomenclature is not an official designation from the Max-Planck Institute of Immunobiology (MPI). It was merely used to indicate that the C57BL/6J mice came from the colony maintained at MPI. As they had been maintained many years in isolation, they were probably technically a new substrain (Dear TN et al.; Development; v. 121, pp. 2909-15, 1995) |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous see Breeding History males, heterozygous see Breeding History females |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- absent spleen / MGI
- nervous system phenotype / MGI
- increased lymphocyte cell number / MGI
- embryo phenotype / MGI
- increased splenocyte apoptosis / MGI
- abnormal spleen development / MGI
- increased number of Howell-Jolly bodies / MGI
- abnormal spleen mesenchyme morphology / MGI
Literature references
- The Hox11 gene is essential for cell survival during spleen development.;Dear T N, Colledge W H, Carlton M B, Lavenir I, Larson T, Smith A J, Warren A J, Evans M J, Sofroniew M V, Rabbitts T H, ;1995;Development (Cambridge, England);121;2909-15; 7555717