C57BL/6-Tg(Gabra6-Bmi1)1004Mro/H
| Status | Available to order |
| EMMA ID | EM:04334 |
| Citation information | RRID:IMSR_EM:04334 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Gabra6-Bmi1)1004Mro/H |
| Alternative name | alpha6-Bmi1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Gabra6-Bmi1)1004Mro |
| Gene/Transgene symbol | Tg(Gabra6-Bmi1)1004Mro |
Information from provider
| Provider | Silvia Marino |
| Provider affiliation | ICMS, Queen Mary University of London |
| Genetic information | Overexpression of Bmi1 in postmitotic granule cell progenitors of the cerebellum. |
| Phenotypic information | Currently characterising the phenotype. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6 males, wild-type C57BL/6J females |
| Breeding at archiving centre | Males imported directly from the depositor were crossed to C57BL/6J females for embryo freezing. |
| Stage of embryos | 2-cell |
Literature references
- Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation.;Behesti Hourinaz, Bhagat Heeta, Dubuc Adrian M, Taylor Michael D, Marino Silvia, ;2013;Disease models & mechanisms;6;49-63; 23065639