| Status | Available to order |
| EMMA ID | EM:04338 |
| Citation information | RRID:IMSR_EM:04338 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Prnptm1Cwe Tg(Prnp/PRNP*ARR)FM16Pcg/H |
| Alternative name | Tg(OvPrP)FM16 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp/PRNP*ARR)FM16Pcg, Prnptm1Cwe |
| Gene/Transgene symbol | Tg(Prnp/PRNP*ARR)FM16Pcg, Prnp |
| Provider | Peter Griffiths |
| Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
| Genetic information | A ~12 kb transgene, comprised of chimaeric DNA sequence encoding a sheep PrP (ARR allele) coding region and mouse PrP gene promoter and 3'-UTR, was used to microinject pronuclear stage FVB/N fertilised oocytes. |
| Phenotypic information | Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice. |
| Breeding history | Bred to 9 generations by crossing with PrP null (Zurich I) mice. Maintained as a transgene heterozygous line. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous males, heterozygous females |
| Breeding at archiving centre | No breeding was performed at the archiving centre. |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
