IMPC phenotypes (gene matching)
B6;129-Prss8tm1Hum/Orl
| Status | Available to order |
| EMMA ID | EM:04402 |
| Citation information | RRID:IMSR_EM:04402 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Prss8tm1Hum/Orl |
| Alternative name | Prss8 lox/lox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Prss8tm1Hum |
| Gene/Transgene symbol | Prss8 |
Information from provider
| Provider | Edith Hummler |
| Provider affiliation | Pharmacology & Toxicology, University of Lausanne |
| Genetic information | In addition to an FRT flanked neo cassette and a downstream 5' flank loxP site inserted into intron 2, a 3' flank loxP site was inserted into intron 5. The floxed region contained exons 3 through 5. Northern blot analysis showed reduced levels of transcript in heterozygous and homozygous mutant mice. |
| Phenotypic information | No phenotype. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N males, wild-type C57BL/6N females |
Disease and phenotype information
MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
MGI phenotypes (gene matching)
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- underdeveloped hair follicles / MGI
- sparse hair / MGI
- short hair / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- curly vibrissae / MGI
- kinked vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- dehydration / MGI
- abnormal coat appearance / MGI
- disheveled coat / MGI
- abnormal hair growth / MGI
- abnormal vibrissa morphology / MGI
- no abnormal phenotype detected / MGI
- impaired skin barrier function / MGI
- delayed wound healing / MGI
- no phenotypic analysis / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair medulla / MGI
- dry skin / MGI
- decreased survivor rate / MGI
- rough coat / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
Literature references
- A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus.;Rubera Isabelle, Meier Evelyne, Vuagniaux Grégoire, Mérillat Anne-Marie, Beermann Friedrich, Rossier Bernard C, Hummler Edith, ;2002;Genesis (New York, N.Y. : 2000);32;173-6; 11857812