MGI phenotypes (gene matching)
B6;129-Tsc22d3tm1Hum/Orl
| Status | Available to order |
| EMMA ID | EM:04415 |
| Citation information | RRID:IMSR_EM:04415 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Tsc22d3tm1Hum/Orl |
| Alternative name | Tsc22d3 gilz |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tsc22d3tm1Hum |
| Gene/Transgene symbol | Tsc22d3 |
Information from provider
| Provider | Edith Hummler |
| Provider affiliation | Pharmacology & Toxicology, University of Lausanne |
| Genetic information | Targeting construct is derived from 129/SvEv DNA. Conditional knockout by use of Cre-loxP and Frt-flp-mediated recombination system. Exons 3-5 are floxed by loxP sites. The FRT-flanked neo cassette has been located after the 5th exon, 3' of the polyA signal. The knockout of this sequence should delete all three major 3/4 isoforms of Tsc22d3 (GILZ: glucocorticoid-induced leucine zipper) |
| Phenotypic information | LoxP/LoxP mice have no phenotype (conditional allele). We already generated the knockout allele, the mice are viable, but males are sterile. Further characterization of the knockout allele is ongoing. |
| Breeding history | Mice are C57BL/6N x 129/SvEv; currently crossed to C57BL/6N. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N males, wild-type C57BL/6N females |
| Breeding at archiving centre | Hemizygous males crossed with wild-type females. After rederivation only females will be heterozygous. |