B6.Cg-Lcktm1Mal/Orl

Status

Available to order

EMMA IDEM:04457
Citation informationRRID:IMSR_EM:04457 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.Cg-Lcktm1Mal/Orl
Alternative nameB6-Lck tm1Mal
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolLcktm1Mal
Gene/Transgene symbolLck

Information from provider

ProviderBernard Malissen
Provider affiliationCentre D
Genetic informationTargeting construct is derived from C57BL/6 DNA. The point mutation transforms amino acid tyrosine 505 in phenylalanine in the protein sequence.
Phenotypic informationAltered Lck (lymphocyte protein tyrosine kinase) activity.
Breeding historyInbred. Bruce 4 ES cells.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivinghomozygous males, wild-type C57BL/6J females

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal thymus morphology / MGI
  • decreased thymocyte number / MGI
  • decreased IgG level / MGI
  • thymus hypoplasia / MGI
  • increased activated T cell number / MGI
  • abnormal T cell differentiation / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal lymphocyte morphology / MGI
  • thymus atrophy / MGI
  • abnormal thymocyte activation / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • decreased T cell number / MGI
  • decreased cytotoxic T cell cytolysis / MGI
  • decreased double-positive T cell number / MGI
  • decreased T cell proliferation / MGI
  • abnormal T cell morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal CD4-positive T cell differentiation / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal CD8-positive, alpha-beta T cell differentiation / MGI
  • abnormal single-positive T cell number / MGI
  • increased single-positive T cell number / MGI
  • decreased single-positive T cell number / MGI
  • decreased gamma-delta T cell number / MGI
  • decreased gamma-delta intraepithelial T cell number / MGI
  • abnormal alpha-beta intraepithelial T cell morphology / MGI
  • decreased IgG1 level / MGI
  • increased IgG2a level / MGI
  • increased IgG3 level / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • abnormal intraepithelial T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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