B6.129-Hspa13tm1Yah Runx1tm1Yg/Orl

Status

Available to order

EMMA IDEM:04460
Citation informationRRID:IMSR_EM:04460 

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International strain nameB6.129-Hspa13tm1Yah Runx1tm1Yg/Orl
Alternative nameCis(Stch<5HP>;Runx1)
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolRunx1tm1Yg, Hspa13tm1Yah
Gene/Transgene symbolRunx1, Hspa13

Information from provider

ProviderYann Herault
Provider affiliationCNRS IEM UMR 6218
Genetic informationInsertion by homologous recombination of a targeting vector containing a loxP site within the locus of Stch (Hspa13) gene, then crossing with a line having a second loxP on the locus of Runx1 gene. After selection the two sites loxP are in cis on the same homologous chromosome. Conditional deletion of mouse chromosome 16 (homologous human chromosome 21) between Stch-Runx1 genes by cre-lox system.
Phenotypic informationNo phenotype. Conditional deletion of mouse chromosome 16 (homologous human chromosome 21) between Stch (Hspa13)-Runx1 genes by cre-lox system.
Breeding historyC57BL/6 backcross for more than 6 generations.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Breeding at archiving centreMales heterozygous for each mutation. Crossed with C57BL/6 females.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • anemia / MGI
  • internal hemorrhage / MGI
  • embryonic lethality / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • decreased body size / MGI
  • thymus hypoplasia / MGI
  • abnormal definitive hematopoiesis / MGI
  • abnormal T cell differentiation / MGI
  • abnormal thymus lobule morphology / MGI
  • increased double-positive T cell number / MGI
  • abnormal leukopoiesis / MGI
  • decreased single-positive T cell number / MGI
  • slow postnatal weight gain / MGI
  • increased thymocyte apoptosis / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • postnatal lethality, complete penetrance / MGI
  • thymus cysts / MGI
  • intracranial hemorrhage / MGI
  • spinal hemorrhage / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • increased monocyte cell number / MGI
  • decreased leukocyte cell number / MGI
  • abnormal megakaryocyte differentiation / MGI
  • abnormal erythropoiesis / MGI
  • abnormal angiogenesis / MGI
  • increased granulocyte number / MGI
  • pale liver / MGI
  • enlarged spleen / MGI
  • small spleen / MGI
  • abnormal Peyer's patch morphology / MGI
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anemia / MGI
  • abnormal myelopoiesis / MGI
  • impaired myelopoiesis / MGI
  • impaired hematopoiesis / MGI
  • internal hemorrhage / MGI
  • postnatal growth retardation / MGI
  • skin edema / MGI
  • thymus hypoplasia / MGI
  • lung inflammation / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • intraventricular hemorrhage / MGI
  • neoplasm / MGI
  • increased T cell derived lymphoma incidence / MGI
  • neonatal lethality / MGI
  • abnormal definitive hematopoiesis / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal axillary lymph node morphology / MGI
  • abnormal inguinal lymph node morphology / MGI
  • abnormal spleen white pulp morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • abnormal thymus medulla morphology / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal megakaryocyte progenitor cell morphology / MGI
  • abnormal megakaryocyte morphology / MGI
  • abnormal erythrocyte morphology / MGI
  • abnormal lymph organ development / MGI
  • decreased mean corpuscular volume / MGI
  • increased mean platelet volume / MGI
  • decreased erythrocyte cell number / MGI
  • no phenotypic analysis / MGI
  • increased erythrocyte cell number / MGI
  • thrombocytopenia / MGI
  • abnormal vascular branching morphogenesis / MGI
  • aneurysm / MGI
  • abnormal embryonic hematopoiesis / MGI
  • abnormal pericyte morphology / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal vitelline vascular remodeling / MGI
  • increased hematopoietic stem cell number / MGI
  • decreased hematopoietic stem cell number / MGI
  • dilated vasculature / MGI
  • decreased lymphocyte cell number / MGI
  • increased double-positive T cell number / MGI
  • hemopericardium / MGI
  • embryo phenotype / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • increased macrophage cell number / MGI
  • hemoperitoneum / MGI
  • abnormal leukopoiesis / MGI
  • thrombocytosis / MGI
  • increased hemoglobin content / MGI
  • spinal hemorrhage / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • decreased Peyer's patch number / MGI
  • small Peyer's patches / MGI
  • increased pro-B cell number / MGI
  • increased mature B cell number / MGI
  • decreased immature B cell number / MGI
  • abnormal leukocyte morphology / MGI
  • slow postnatal weight gain / MGI
  • embryonic lethality / MGI
  • abnormal erythroid progenitor cell morphology / MGI
  • decreased erythroid progenitor cell number / MGI
  • increased nucleated erythrocyte cell number / MGI
  • increased thymocyte apoptosis / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • increased red blood cell distribution width / MGI
  • myeloid hyperplasia / MGI
  • mortality/aging / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased hematopoietic cell number / MGI
  • decreased pre-pro B cell number / MGI
  • embryo tissue necrosis / MGI
  • thymus cysts / MGI

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