IMPC phenotypes (gene matching)
B6.129-Apptm1Yah Runx1tm1Yg/+ +/Orl
| Status | Available to order |
| EMMA ID | EM:04461 |
| Citation information | RRID:IMSR_EM:04461 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Apptm1Yah Runx1tm1Yg/+ +/Orl |
| Alternative name | Cis (APP<3RT;Runx1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Runx1tm1Yg, Apptm1Yah |
| Gene/Transgene symbol | Runx1, App |
Information from provider
| Provider | Yann Herault |
| Provider affiliation | CNRS IEM UMR 6218 |
| Genetic information | Insertion by homologous recombination of a targeting vector containing a loxP site within the locus of App gene, then crossing with a line having a second loxP on the locus of Runx1 gene. After selection the two loxP sites are in cis on the same homologous chromosome. Conditional deletion of mouse chromosome 16 (homologous human chromosome 21) between App-Runx1 genes by cre-lox system. |
| Phenotypic information | Conditional deletion of mouse chromosome 16 (homologous human chromosome 21) between App-Runx1 genes by cre-lox system. |
| Breeding history | C57BL/6 backcross for more than 6 generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Breeding at archiving centre | Males heterozygous for each mutation. Crossed with wild-type C57BL/6J females. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- ABeta amyloidosis, Italian type / Orphanet_324713
- ABetaL34V amyloidosis / Orphanet_324703
- ABeta amyloidosis, Arctic type / Orphanet_324723
- ABetaA21G amyloidosis / Orphanet_324718
- ABeta amyloidosis, Dutch type / Orphanet_100006
- ABeta amyloidosis, Iowa type / Orphanet_324708
- Early-onset autosomal dominant Alzheimer disease / Orphanet_1020
- Aggressive systemic mastocytosis / Orphanet_98850
- Familial platelet disorder with associated myeloid malignancy / Orphanet_71290
- Isolated delta-storage pool disease / Orphanet_248340
MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
- anemia / MGI
- internal hemorrhage / MGI
- embryonic lethality / MGI
- abnormal bone marrow cell morphology/development / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- decreased body size / MGI
- thymus hypoplasia / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal T cell differentiation / MGI
- abnormal thymus lobule morphology / MGI
- increased double-positive T cell number / MGI
- abnormal leukopoiesis / MGI
- decreased single-positive T cell number / MGI
- slow postnatal weight gain / MGI
- increased thymocyte apoptosis / MGI
- abnormal thymus corticomedullary boundary morphology / MGI
- postnatal lethality, complete penetrance / MGI
- thymus cysts / MGI
- intracranial hemorrhage / MGI
- spinal hemorrhage / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
MGI phenotypes (gene matching)
- amyloidosis / MGI
- muscle degeneration / MGI
- decreased corpus callosum size / MGI
- abnormal telencephalon morphology / MGI
- decreased body weight / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- decreased exploration in new environment / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- impaired swimming / MGI
- intracerebral hemorrhage / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal fear/anxiety-related behavior / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- decreased brain weight / MGI
- gliosis / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- abnormal long term potentiation / MGI
- abnormal emotion/affect behavior / MGI
- increased thigmotaxis / MGI
- abnormal active avoidance behavior / MGI
- abnormal long term object recognition memory / MGI
- abnormal neuron morphology / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- amyloid beta deposits / MGI
- astrocytosis / MGI
- nervous system phenotype / MGI
- impaired passive avoidance behavior / MGI
- myositis / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal spatial reference memory / MGI
- hematoma / MGI
- microgliosis / MGI
- increased variability of skeletal muscle fiber size / MGI
- centrally nucleated skeletal muscle fibers / MGI
- abnormal synapse morphology / MGI
- decreased grip strength / MGI
- altered susceptibility to induced thrombosis / MGI
- abnormal circadian behavior / MGI
- decreased hematocrit / MGI
- increased monocyte cell number / MGI
- decreased leukocyte cell number / MGI
- abnormal megakaryocyte differentiation / MGI
- abnormal erythropoiesis / MGI
- abnormal angiogenesis / MGI
- increased granulocyte number / MGI
- pale liver / MGI
- enlarged spleen / MGI
- small spleen / MGI
- abnormal Peyer's patch morphology / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- decreased body weight / MGI
- decreased body size / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- impaired myelopoiesis / MGI
- impaired hematopoiesis / MGI
- internal hemorrhage / MGI
- postnatal growth retardation / MGI
- skin edema / MGI
- thymus hypoplasia / MGI
- lung inflammation / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- intraventricular hemorrhage / MGI
- neoplasm / MGI
- increased T cell derived lymphoma incidence / MGI
- neonatal lethality / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal axillary lymph node morphology / MGI
- abnormal inguinal lymph node morphology / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal thymus lobule morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal megakaryocyte progenitor cell morphology / MGI
- abnormal megakaryocyte morphology / MGI
- abnormal erythrocyte morphology / MGI
- abnormal lymph organ development / MGI
- decreased mean corpuscular volume / MGI
- increased mean platelet volume / MGI
- decreased erythrocyte cell number / MGI
- no phenotypic analysis / MGI
- increased erythrocyte cell number / MGI
- thrombocytopenia / MGI
- abnormal vascular branching morphogenesis / MGI
- aneurysm / MGI
- abnormal embryonic hematopoiesis / MGI
- abnormal pericyte morphology / MGI
- abnormal T cell subpopulation ratio / MGI
- abnormal vitelline vascular remodeling / MGI
- increased hematopoietic stem cell number / MGI
- decreased hematopoietic stem cell number / MGI
- dilated vasculature / MGI
- decreased lymphocyte cell number / MGI
- increased double-positive T cell number / MGI
- hemopericardium / MGI
- embryo phenotype / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased macrophage cell number / MGI
- hemoperitoneum / MGI
- abnormal leukopoiesis / MGI
- thrombocytosis / MGI
- increased hemoglobin content / MGI
- spinal hemorrhage / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- decreased Peyer's patch number / MGI
- small Peyer's patches / MGI
- increased pro-B cell number / MGI
- increased mature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal leukocyte morphology / MGI
- slow postnatal weight gain / MGI
- embryonic lethality / MGI
- abnormal erythroid progenitor cell morphology / MGI
- decreased erythroid progenitor cell number / MGI
- increased nucleated erythrocyte cell number / MGI
- increased thymocyte apoptosis / MGI
- abnormal thymus corticomedullary boundary morphology / MGI
- increased red blood cell distribution width / MGI
- myeloid hyperplasia / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- decreased hematopoietic cell number / MGI
- decreased pre-pro B cell number / MGI
- embryo tissue necrosis / MGI
- thymus cysts / MGI