| Status | Available to order |
| EMMA ID | EM:04481 |
| Citation information | RRID:IMSR_EM:04481 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S/Sv-Gstz1tm1Jmfc/Cnbc |
| Alternative name | MAAI/GSTZ deficient |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gstz1tm1Jmfc |
| Gene/Transgene symbol | Gstz1 |
| Provider | Jose Manuel Fernandez-Canon |
| Provider affiliation | Instituto de Biologia Malecular, Genomica y Proteomica, Universidad de leon |
| Genetic information | Removal of 60% of the Maai (Gstz1) gene (coding region). |
| Phenotypic information | Deficient in the MAAI/GSTZ enzyme (no enzymatic activity), involved in the catabolic pathway of phenylalanine/tyrosine. Sensitive to high phenylalanine diet. Accumulates maleylacetoacetate (MAA) and fumarylacetoacetate (FAA), which are toxic compounds. |
| Breeding history | Mutant mice were generated in 2001. They have been backcrossed with 129/SvPas (Charles River Lab) in 2003 to avoid strain degeneration. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous 129S2/SvPas males, wild-type 129S2/SvPas females |
| Stage of embryos | 8-cell |
