MGI phenotypes (allele matching)
B6.129P2(Cg)-Dazltm1Hjc/H
| Status | Available to order |
| EMMA ID | EM:04536 |
| Citation information | RRID:IMSR_EM:04536 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2(Cg)-Dazltm1Hjc/H |
| Alternative name | Dazl hgutm1 /C57Bl6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Dazltm1Hjc |
| Gene/Transgene symbol | Dazl |
Information from provider
| Provider | Howard Cooke |
| Provider affiliation | Department of Medical & Developmental Genetics, MRC Human Genetics Unit |
| Genetic information | A C129 derived targeting construct was used to disrupt the RNA binding domain of the Dazl locus. |
| Phenotypic information | Mice homozygous for this mutation in this background lack germ cells at birth in both sexes. Heterozygous mice show close to normal fertility. |
| Breeding history | Founder males were initially crossed onto CD1 outbred females. Subsequently males were backcrossed 10 generations to C57BL/6J. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J males |
| Breeding at archiving centre | None. Males were archived at the time of arrival at the archiving centre. |
Disease and phenotype information
Literature references
- The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.;Ruggiu M, Speed R, Taggart M, McKay S J, Kilanowski F, Saunders P, Dorin J, Cooke H J, ;1997;Nature;389;73-7; 9288969