B6.129S4(CD1)-Syce2Gt(FHCRC-GT-S8-7E1)Sor/H

Status

Available to order

EMMA IDEM:04537
Citation informationRRID:IMSR_EM:04537 

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International strain nameB6.129S4(CD1)-Syce2Gt(FHCRC-GT-S8-7E1)Sor/H
Alternative nameSyce2KO /C57Bl6
Strain typeGene-trap
Allele/Transgene symbolSyce2Gt(FHCRC-GT-S8-7E1)Sor
Gene/Transgene symbolSyce2

Information from provider

ProviderHoward Cooke
Provider affiliationDepartment of Medical & Developmental Genetics, MRC Human Genetics Unit
Genetic informationThe gene trap vector ROSAFARY is inserted into exon 2 creating a null allele. No protein was detected in testis cell spreads.
Phenotypic informationMice homozygous for this mutation in this background can not progress to diplotene stages of meiosis and show a failure of synapsis. Heterozygous mice show close to normal fertility.
Breeding historyFounder males were initially crossed onto CD1 outbred females. Subsequently males were backcrossed for 10 generations to C57BL/6J.
References
  • SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.;Bolcun-Filas Ewelina, Costa Yael, Speed Robert, Taggart Mary, Benavente Ricardo, De Rooij Dirk G, Cooke Howard J, ;2007;The Journal of cell biology;176;741-7; 17339376
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6J males
Breeding at archiving centreNone. Males were archived at the time of arrival at the archiving centre.

Disease and phenotype information

IMPC phenotypes (gene matching)
  • aspermia / IMPC
  • increased total body fat amount / IMPC
  • small kidney / IMPC
  • decreased grip strength / IMPC
  • decreased lean body mass / IMPC
  • decreased bone mineral density / IMPC
  • developmental dysplasia / IMPC
  • abnormal skin morphology / IMPC
  • small epididymis / IMPC
  • small testis / IMPC
  • decreased bone mineral content / IMPC
  • hypoplasia / IMPC
  • dysplasia / IMPC
  • male infertility / IMPC
  • spermatogenesis defect / IMPC
  • female infertility / IMPC
  • enlarged urinary bladder / IMPC
MGI phenotypes (allele matching)
  • small ovary / MGI
  • male infertility / MGI
  • female infertility / MGI
  • decreased testis weight / MGI
  • abnormal female meiosis / MGI
  • abnormal male meiosis / MGI
  • arrest of male meiosis / MGI
MGI phenotypes (gene matching)
  • small ovary / MGI
  • male infertility / MGI
  • female infertility / MGI
  • decreased testis weight / MGI
  • abnormal female meiosis / MGI
  • abnormal male meiosis / MGI
  • arrest of male meiosis / MGI

Literature references

  • SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.;Bolcun-Filas Ewelina, Costa Yael, Speed Robert, Taggart Mary, Benavente Ricardo, De Rooij Dirk G, Cooke Howard J, ;2007;The Journal of cell biology;176;741-7; 17339376

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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