B6.129S4-Cd14tm1Frm/Orl

Status

Available to order

EMMA IDEM:00454
Citation informationRRID:IMSR_EM:00454 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129S4-Cd14tm1Frm/Orl
Alternative nameCD14 (lps)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd14tm1Frm
Gene/Transgene symbolCd14

Information from provider

ProviderB Ryffel
Provider affiliationTAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models
Phenotypic informationCD14 antigen (endotoxin receptor) mutant.
References
  • Divergent response to LPS and bacteria in CD14-deficient murine macrophages.;Moore K J, Andersson L P, Ingalls R R, Monks B G, Li R, Arnaout M A, Golenbock D T, Freeman M W, ;2000;Journal of immunology (Baltimore, Md. : 1950);165;4272-80; 11035061

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal cytokine secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • increased bone mineral density / MGI
  • pulmonary edema / MGI
  • increased lean body mass / MGI
  • increased bone mass / MGI
  • abnormal cytokine level / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • decreased susceptibility to bone fracture / MGI
  • decreased total body fat amount / MGI
  • increased bone mineral content / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal interferon secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • abnormal cytokine secretion / MGI
  • pulmonary edema / MGI
  • increased lean body mass / MGI
  • increased bone mass / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • abnormal interferon secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal cytokine level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • decreased susceptibility to bone fracture / MGI
  • decreased total body fat amount / MGI
  • increased bone mineral content / MGI

Literature references

  • Divergent response to LPS and bacteria in CD14-deficient murine macrophages.;Moore K J, Andersson L P, Ingalls R R, Monks B G, Li R, Arnaout M A, Golenbock D T, Freeman M W, ;2000;Journal of immunology (Baltimore, Md. : 1950);165;4272-80; 11035061

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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