IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
B6;129-Atg16l1tm1.1Kuv/Orl
| Status | Available to order |
| EMMA ID | EM:04563 |
| Citation information | RRID:IMSR_EM:04563 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Atg16l1tm1.1Kuv/Orl |
| Alternative name | B6.129Sv-Atg16l1tm1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Atg16l1tm1.1Kuv |
| Gene/Transgene symbol | Atg16l1 |
Information from provider
| Provider | Philip ROSENSTIEL |
| Provider affiliation | IKMB, University of Kiel |
| Genetic information | Constitutive knockout of Atg16l1. Details available upon request. |
| Phenotypic information | Not known. |
| Breeding history | Backcrossed to C57BL/6 for less than 5 generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- overriding aortic valve / MGI
- prenatal lethality / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- increased circulating serum albumin level / MGI
- abnormal eye muscle morphology / MGI
- abnormal Paneth cell morphology / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- increased mean corpuscular hemoglobin / MGI
- abnormal autophagy / MGI
- increased susceptibility to induced colitis / MGI
- increased circulating interleukin-1 beta level / MGI
- increased interleukin-1 beta secretion / MGI
- increased interleukin-18 secretion / MGI
- thoracoschisis / MGI
- perimembraneous ventricular septal defect / MGI
- abnormal hepatic vein morphology / MGI
- abnormal inferior vena cava valve morphology / MGI
- increased macrophage cytokine production / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal intrathoracic topology of vagus nerve / MGI
- absent hypoglossal nerve / MGI
- abnormal hypoglossal nerve topology / MGI
- absent segment of posterior cerebral artery / MGI
- subcutaneous edema / MGI
- absent ductus venosus valve / MGI
- abnormal thymus topology / MGI
- absent connection between subcutaneous lymph vessels and lymph sac / MGI
- blood in lymph vessels / MGI
- abnormal vitelline vein topology / MGI