B6;129-Ahr^tm1Bra Tg(EEF1A1-Ahr*)1Pjvt/Kctt

Status	Available to order
EMMA ID	EM:04604
Citation information	RRID:IMSR_EM:04604 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129-Ahr^tm1Bra Tg(EEF1A1-Ahr*)1Pjvt/Kctt
Alternative name	C57BL/6-Tg INS-rat AH receptor
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Ahr^tm1Bra, Tg(EEF1A1-Ahr*)1Pjvt
Gene/Transgene symbol	Ahr, Tg(EEF1A1-Ahr*)1Pjvt

Information from provider

Provider	Raimo Pohjanvirta
Provider affiliation	University of Helsinki
Genetic information	The insertion variant of rat Ahr gene was transferred into C57BL/6JOlaHsd by microinjection. Construct positive offspring were mated with Ahr-null mice to get rid of innate mouse Ahr.
Phenotypic information	High resistance to the acute toxicity of dioxins, while sensitivity to induction of drug-metabolizing enzymes by dioxins is retained.
Breeding history	Construct positive offspring were mated with Ahr-null mice derived from the C57BL/6J strain to get rid of innate mouse Ahr. The Ahr-null mice are also currently used with transgenic construct-positive, mouse AhR-negative mice in breeding the line, as breeding homozygous animals together has in some cases resulted in increased lethality of progeny.
References	Transgenic mouse lines expressing rat AH receptor variants--a new animal model for research on AH receptor function and dioxin toxicity mechanisms.;Pohjanvirta Raimo, ;2009;Toxicology and applied pharmacology;236;166-82; 19371626
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Retinitis pigmentosa / Orphanet_791

MGI phenotypes (allele matching)

lung inflammation / MGI
increased susceptibility to bacterial infection / MGI
abnormal macrophage physiology / MGI
abnormal ovary physiology / MGI
pulmonary edema / MGI
increased susceptibility to injury / MGI
abnormal enzyme/coenzyme activity / MGI
abnormal cytokine level / MGI
abnormal chemokine level / MGI
abnormal interleukin level / MGI
abnormal tumor necrosis factor level / MGI
increased physiological sensitivity to xenobiotic / MGI
abnormal primordial ovarian follicle morphology / MGI
pulmonary alveolar edema / MGI
abnormal kidney blood vessel morphology / MGI
abnormal hepatocyte morphology / MGI
small prostate gland anterior lobe / MGI
increased body weight / MGI
abnormal blood vessel morphology / MGI
decreased liver weight / MGI
patent ductus venosus / MGI
decreased seminal vesicle weight / MGI
abnormal circulating hormone level / MGI
decreased physiological sensitivity to xenobiotic / MGI
abnormal liver sinusoid morphology / MGI
small prostate gland dorsolateral lobe / MGI
persistent hyaloid artery / MGI
extramedullary hematopoiesis / MGI
small liver / MGI
pale liver / MGI
enlarged spleen / MGI
decreased body weight / MGI
postnatal growth retardation / MGI
hepatic steatosis / MGI
abnormal cytokine secretion / MGI
abnormal keratinocyte physiology / MGI
liver hyperplasia / MGI
abnormal Langerhans cell physiology / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
abnormal Langerhans cell morphology / MGI
decreased spleen germinal center size / MGI
abnormal branching of the mammary ductal tree / MGI
small ovary / MGI
abnormal ovarian folliculogenesis / MGI
abnormal ovulation / MGI
decreased germ cell number / MGI
decreased corpora lutea number / MGI
decreased ovary weight / MGI
abnormal superovulation / MGI

MGI phenotypes (gene matching)

extramedullary hematopoiesis / MGI
abnormal heart morphology / MGI
enlarged heart / MGI
abnormal coat/ hair morphology / MGI
folliculitis / MGI
abnormal hair follicle morphology / MGI
abnormal auchene hair morphology / MGI
alopecia / MGI
rectal prolapse / MGI
abnormal colon morphology / MGI
abnormal kidney blood vessel morphology / MGI
abnormal urinary bladder morphology / MGI
abnormal urinary bladder urothelium morphology / MGI
abnormal liver morphology / MGI
small liver / MGI
pale liver / MGI
abnormal hepatocyte morphology / MGI
abnormal liver physiology / MGI
abnormal branching of the mammary ductal tree / MGI
small prostate gland anterior lobe / MGI
abnormal spleen morphology / MGI
enlarged spleen / MGI
small spleen / MGI
spleen hypoplasia / MGI
abnormal uterus morphology / MGI
small ovary / MGI
abnormal ovarian folliculogenesis / MGI
seminiferous tubule degeneration / MGI
abnormal skin condition / MGI
scaly skin / MGI
thick skin / MGI
spontaneous skin ulceration / MGI
skin lesions / MGI
abnormal epidermal layer morphology / MGI
increased body weight / MGI
decreased body weight / MGI
weight loss / MGI
disorganized retinal layers / MGI
abnormal blood vessel morphology / MGI
chronic diarrhea / MGI
postnatal growth retardation / MGI
abnormal immune system physiology / MGI
increased inflammatory response / MGI
heart inflammation / MGI
abnormal atrial thrombosis / MGI
lung inflammation / MGI
acanthosis / MGI
reduced female fertility / MGI
abnormal ovulation / MGI
decreased litter size / MGI
premature death / MGI
decreased germ cell number / MGI
abnormal spleen red pulp morphology / MGI
increased susceptibility to bacterial infection / MGI
abnormal macrophage physiology / MGI
hepatic steatosis / MGI
abnormal cauda epididymis morphology / MGI
decreased corpora lutea number / MGI
colitis / MGI
increased heart weight / MGI
vascular smooth muscle hypertrophy / MGI
abnormal cytokine secretion / MGI
no phenotypic analysis / MGI
cardiac fibrosis / MGI
bile duct inflammation / MGI
gastric polyps / MGI
increased liver adenoma incidence / MGI
liver fibrosis / MGI
decreased liver weight / MGI
abnormal keratinocyte physiology / MGI
abnormal ovary physiology / MGI
nervous system phenotype / MGI
abnormal hair shaft morphology / MGI
pulmonary edema / MGI
patent ductus venosus / MGI
abnormal coronary artery morphology / MGI
abnormal spermiation / MGI
increased incidence of tumors by chemical induction / MGI
decreased testis weight / MGI
decreased ovary weight / MGI
decreased seminal vesicle weight / MGI
decreased epididymis weight / MGI
increased spleen weight / MGI
abnormal thrombosis / MGI
liver hyperplasia / MGI
increased susceptibility to injury / MGI
abnormal Langerhans cell physiology / MGI
renal/urinary system phenotype / MGI
homeostasis/metabolism phenotype / MGI
reproductive system phenotype / MGI
skeleton phenotype / MGI
abnormal circulating hormone level / MGI
teratozoospermia / MGI
abnormal enzyme/coenzyme activity / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
abnormal Langerhans cell morphology / MGI
abnormal male germ cell apoptosis / MGI
decreased spleen white pulp amount / MGI
decreased spleen germinal center size / MGI
abnormal cytokine level / MGI
abnormal chemokine level / MGI
abnormal interleukin level / MGI
abnormal tumor necrosis factor level / MGI
increased physiological sensitivity to xenobiotic / MGI
decreased physiological sensitivity to xenobiotic / MGI
abnormal xenobiotic pharmacokinetics / MGI
abnormal liver sinusoid morphology / MGI
abnormal sperm head morphology / MGI
coiled sperm flagellum / MGI
abnormal primordial ovarian follicle morphology / MGI
increased urinary bladder carcinoma incidence / MGI
hypergranulosis / MGI
abnormal optokinetic reflex / MGI
urinary bladder inflammation / MGI
decreased fertilization frequency / MGI
abnormal superovulation / MGI
small prostate gland dorsolateral lobe / MGI
increased sensitivity to xenobiotic induced morbidity/mortality / MGI
decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
increased urine uric acid level / MGI
increased hepatoma incidence / MGI
abnormal stomach pyloric region morphology / MGI
pulmonary alveolar edema / MGI
abnormal horizontal vestibuloocular reflex / MGI
postnatal lethality, incomplete penetrance / MGI
cystolithiasis / MGI
abnormal seminiferous tubule epithelium morphology / MGI
urinary bladder fibrosis / MGI
abnormal urinary bladder blood vessel morphology / MGI
persistent hyaloid artery / MGI
multinucleated giant male germ cells / MGI
dilated piliary canal / MGI

Literature references

Transgenic mouse lines expressing rat AH receptor variants--a new animal model for research on AH receptor function and dioxin toxicity mechanisms.;Pohjanvirta Raimo, ;2009;Toxicology and applied pharmacology;236;166-82; 19371626

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6;129-Ahrtm1Bra Tg(EEF1A1-Ahr*)1Pjvt/Kctt