CBA/Ca-Tg(TcraBM3.3,TcrbBM3.3)1Alm/Orl

Status	Available to order
EMMA ID	EM:04614
Citation information	RRID:IMSR_EM:04614 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	CBA/Ca-Tg(TcraBM3.3,TcrbBM3.3)1Alm/Orl
Alternative name	BM3.3 TCR Tg
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(TcraBM3.3,TcrbBM3.3)1Alm
Gene/Transgene symbol	Tg(TcraBM3.3,TcrbBM3.3)1Alm

Information from provider

Provider	Annick Guimezanes
Provider affiliation	CIML
Genetic information	Mice express BM3.3 TCR alpha and beta genes on CBA/Ca background.
Phenotypic information	T cells from TCR Tg mice express the BM3.3 TCR (anti-H-2Kb+pBM1). CD8+ T cells are positively selected and express high level of BM3.3 TCR, CD4+ T cells are not positively selected but some express a low level of BM3.3 TCR. On RAG deficient background, only CD8+ T cells are present and express TCR Tg.
Breeding history	TCR transgene was injected in fertilized eggs from CBA/Ca parents and was maintained on CBA/Ca background.
References	The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice.;Auphan N, Curnow J, Guimezanes A, Langlet C, Malissen B, Mellor A, Schmitt-Verhulst A M, ;1994;European journal of immunology;24;1572-7; 8026519
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	yes

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous CBA/Ca males, wild-type CBA/Ca females
Breeding at archiving centre	transgenic males (probably homozygous)

Literature references

The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice.;Auphan N, Curnow J, Guimezanes A, Langlet C, Malissen B, Mellor A, Schmitt-Verhulst A M, ;1994;European journal of immunology;24;1572-7; 8026519

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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