C3H.C-Casp3m1H/H

Status

Available to order

EMMA IDEM:04615
Citation informationRRID:IMSR_EM:04615 

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International strain nameC3H.C-Casp3m1H/H
Alternative nameCasp3-I216F
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCasp3m1H
Gene/Transgene symbolCasp3

Information from provider

ProviderShoumo Bhattacharya
Provider affiliationDept of Cardiovascular Medicine, University of Oxford
Additional ownerThe original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. Harwell Science and Innovation Campus Oxfordshire OX11 0RD UK
Genetic informationThe original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males. The molecular lesion is an Isoleucine to Phenylalanine change at amino acid 216 which introduces an MboII restriction site. It has been backcrossed to C3H for 10+ generations. Last SNP genotyping determined only 2 Mb region remaining BALB/c background.
Phenotypic informationReduced apoptosis in homozygotes. Phenocopies Caspase 3 null alleles.
Breeding historyBackcrossed to C3H for 10+ generations.
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C3H/HeH males
Breeding at archiving centreNone. Mice were archived at the time of arrival at the archiving centre.

Disease and phenotype information

MGI phenotypes (gene matching)
  • cochlear degeneration / MGI
  • abnormal organ of Corti morphology / MGI
  • delayed bone ossification / MGI
  • decreased bone mineral density / MGI
  • cleft palate / MGI
  • abnormal bone marrow development / MGI
  • decreased thymocyte number / MGI
  • abnormal forebrain morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal diencephalon morphology / MGI
  • abnormal cerebellum development / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • abnormal cerebellar granule layer morphology / MGI
  • abnormal cerebellar molecular layer / MGI
  • cranioschisis / MGI
  • abnormal ovarian follicle morphology / MGI
  • decreased body size / MGI
  • abnormal eye development / MGI
  • microphthalmia / MGI
  • cataract / MGI
  • abnormal retina morphology / MGI
  • abnormal gait / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal apoptosis / MGI
  • decreased inflammatory response / MGI
  • hydroencephaly / MGI
  • deafness / MGI
  • premature death / MGI
  • abnormal eye morphology / MGI
  • abnormal ear morphology / MGI
  • abnormal skeleton development / MGI
  • abnormal brain morphology / MGI
  • abnormal cochlear hair cell morphology / MGI
  • abnormal olfactory bulb development / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal bone remodeling / MGI
  • no phenotypic analysis / MGI
  • decreased neuron apoptosis / MGI
  • increased cardiomyocyte apoptosis / MGI
  • abnormal lens epithelium morphology / MGI
  • abnormal keratinocyte physiology / MGI
  • nervous system phenotype / MGI
  • abnormal retinal inner nuclear layer morphology / MGI
  • abnormal sagittal suture morphology / MGI
  • abnormal optic stalk morphology / MGI
  • cochlear hair cell degeneration / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • fused outer hair cell stereocilia / MGI
  • absent distortion product otoacoustic emissions / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal brainstem morphology / MGI
  • renal/urinary system phenotype / MGI
  • hearing/vestibular/ear phenotype / MGI
  • cellular phenotype / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal lens development / MGI
  • decreased apoptosis / MGI
  • abnormal olfactory sensory neuron morphology / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • abnormal bone ossification / MGI
  • increased cellular sensitivity to ultraviolet irradiation / MGI
  • abnormal granulosa cell morphology / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced cell death / MGI
  • decreased sensitivity to induced cell death / MGI
  • decreased trabecular bone thickness / MGI
  • decreased keratinocyte apoptosis / MGI
  • postnatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • encephalomeningocele / MGI
  • decreased fibroblast apoptosis / MGI
  • cranial bossing / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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