B6;129-Nlrp6tm1.1Kuv/Orl

Status

Available to order

EMMA IDEM:04650
Citation informationRRID:IMSR_EM:04650 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6;129-Nlrp6tm1.1Kuv/Orl
Alternative nameNalp6 KO, B6.129Sv-Nlr6tm1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNlrp6tm1.1Kuv
Gene/Transgene symbolNlrp6

Information from provider

ProviderPhilip ROSENSTIEL
Provider affiliationIKMB, University of Kiel
Genetic informationDetails available upon request.
Phenotypic informationUnder investigations.
Breeding historyBackcrossed to C57BL/6 for less than 5 generations.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivingheterozygous males, wild-type C57BL/6J females

Disease and phenotype information

MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • abnormal intestinal mucosa morphology / MGI
  • intestinal ulcer / MGI
  • decreased anxiety-related response / MGI
  • hunched posture / MGI
  • impaired wound healing / MGI
  • abnormal associative learning / MGI
  • increased IgA level / MGI
  • decreased urine osmolality / MGI
  • intestinal edema / MGI
  • rectal hemorrhage / MGI
  • increased incidence of tumors by chemical induction / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • increased B cell number / MGI
  • diarrhea / MGI
  • behavior/neurological phenotype / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • enlarged Peyer's patches / MGI
  • increased susceptibility to induced colitis / MGI
  • decreased circulating interleukin-18 level / MGI
  • decreased interleukin-18 secretion / MGI
  • abnormal enterocyte proliferation / MGI
  • increased IgG2c level / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal intestine physiology / MGI
  • increased susceptibility to weight loss / MGI
  • increased gastrointestinal tumor incidence / MGI
  • abnormal gut flora balance / MGI
  • increased urine flow rate / MGI
  • enhanced spatial learning / MGI
  • impaired spatial learning / MGI
  • decreased colon length / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
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