IMPC phenotypes (gene matching)
B6.129P2-Psip1Gt(betageo)1Hgs/H
| Status | Available to order |
| EMMA ID | EM:04660 |
| Citation information | RRID:IMSR_EM:04660 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Psip1Gt(betageo)1Hgs/H |
| Alternative name | Psip1Gt(betageo)1Hgs C57BL/6 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Psip1Gt(betageo)1Hgs |
| Gene/Transgene symbol | Psip1 |
Information from provider
| Provider | Heidi Sutherland |
| Provider affiliation | MRC Human Genetics Unit, Institute of Genetics and Molcular Medicine |
| Genetic information | The Psip1 locus was disrupted by the insertion into intron 8-9 of a gene-trap vector containing a splice acceptor site followed by beta-geo and a polyadenylation signal. |
| Phenotypic information | Perinatal lethal, homozygotes have homeotic transformations and abnormal ribcage. |
| Breeding history | Chimeras have been backcrossed to C57BL/6 for more than 10 generations. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6 males |
| Breeding at archiving centre | None |
Disease and phenotype information
MGI phenotypes (allele matching)
- postnatal lethality, incomplete penetrance / MGI
- mortality/aging / MGI
- abnormal abdominal fat pad morphology / MGI
- abnormal neurocranium morphology / MGI
- abnormal vertebrae morphology / MGI
- abnormal rib morphology / MGI
- asymmetric rib joints / MGI
- broad head / MGI
- shortened head / MGI
- abnormal cranium morphology / MGI
- domed cranium / MGI
- abnormal jaw morphology / MGI
- small testis / MGI
- hypoactivity / MGI
- hunched posture / MGI
- limb grasping / MGI
- reduced male fertility / MGI
- abnormal axial skeleton morphology / MGI
- decreased vertical activity / MGI
- abnormal rib development / MGI
- vertebral transformation / MGI
- abnormal cervical vertebrae morphology / MGI
- decreased rib number / MGI
- spleen atrophy / MGI
- abnormal spine curvature / MGI
- short sternum / MGI
- small interparietal bone / MGI
- small supraoccipital bone / MGI
- small exoccipital bone / MGI
- short nasal bone / MGI
- broad nasal bone / MGI
- abnormal cervical atlas morphology / MGI
- abnormal cervical axis morphology / MGI
- cervical vertebral transformation / MGI
- lumbar vertebral transformation / MGI
- thoracic vertebral transformation / MGI
- decreased lumbar vertebrae number / MGI
- blepharitis / MGI
- vision/eye phenotype / MGI
- absent epididymal fat pad / MGI
- absent gastric milk in neonates / MGI
- decreased total body fat amount / MGI
- decreased grip strength / MGI
- perinatal lethality, incomplete penetrance / MGI
- short face / MGI
- broad face / MGI
- broad occipital bone / MGI
- flat occipital bone / MGI
- abnormal nasal bone morphology / MGI
MGI phenotypes (gene matching)
- abnormal abdominal fat pad morphology / MGI
- abnormal neurocranium morphology / MGI
- abnormal nasal bone morphology / MGI
- abnormal vertebrae morphology / MGI
- abnormal rib morphology / MGI
- asymmetric rib joints / MGI
- broad head / MGI
- shortened head / MGI
- abnormal cranium morphology / MGI
- domed cranium / MGI
- abnormal jaw morphology / MGI
- small testis / MGI
- hypoactivity / MGI
- hunched posture / MGI
- limb grasping / MGI
- reduced male fertility / MGI
- abnormal axial skeleton morphology / MGI
- no abnormal phenotype detected / MGI
- decreased vertical activity / MGI
- abnormal rib development / MGI
- vertebral transformation / MGI
- abnormal cervical vertebrae morphology / MGI
- decreased rib number / MGI
- spleen atrophy / MGI
- abnormal spine curvature / MGI
- short sternum / MGI
- small interparietal bone / MGI
- small supraoccipital bone / MGI
- small exoccipital bone / MGI
- short nasal bone / MGI
- broad nasal bone / MGI
- abnormal cervical atlas morphology / MGI
- abnormal cervical axis morphology / MGI
- cervical vertebral transformation / MGI
- lumbar vertebral transformation / MGI
- thoracic vertebral transformation / MGI
- decreased lumbar vertebrae number / MGI
- blepharitis / MGI
- vision/eye phenotype / MGI
- absent epididymal fat pad / MGI
- absent gastric milk in neonates / MGI
- decreased total body fat amount / MGI
- decreased grip strength / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- short face / MGI
- broad face / MGI
- broad occipital bone / MGI
- flat occipital bone / MGI
Literature references
- Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations.;Sutherland Heidi G, Newton Kathryn, Brownstein David G, Holmes Megan C, Kress Clémence, Semple Colin A, Bickmore Wendy A, ;2006;Molecular and cellular biology;26;7201-10; 16980622