IMPC phenotypes (gene matching)
B6.129P2-Ehmt2Gt(ES62)Feil/H
| Status | Available to order |
| EMMA ID | EM:04661 |
| Citation information | RRID:IMSR_EM:04661 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Ehmt2Gt(ES62)Feil/H |
| Alternative name | Ehmt2Gt(betageo)1Hgs C57BL/6 [same as Ehmt2Gt(ES62)Feil] |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Ehmt2Gt(ES62)Feil |
| Gene/Transgene symbol | Ehmt2 |
Information from provider
| Provider | Heidi Sutherland |
| Provider affiliation | MRC Human Genetics Unit, Institute of Genetics and Molcular Medicine |
| Genetic information | The Ehmt2 locus was disrupted by the insertion into intron 11-12 of the gene-trap vector pGT1-3 containing a beta-geo cassette. |
| Phenotypic information | Homozygotes are embryonic lethal at ca. 8.5 dpc. Show retardation of growth, abnormal imprinting and open neural tube. |
| Breeding history | Chimeras have been backcrossed to C57BL/6 for more than 10 generations. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6 males |
| Breeding at archiving centre | Males were archived by sperm freezing on the day of importation. No breeding was performed at the archiving centre. |
Disease and phenotype information
MGI phenotypes (gene matching)
- open neural tube / MGI
- abnormal apoptosis / MGI
- decreased embryo size / MGI
- decreased trophoblast giant cell number / MGI
- embryonic growth arrest / MGI
- no abnormal phenotype detected / MGI
- abnormal imprinting / MGI
- small placenta / MGI
- abnormal cell physiology / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
Literature references
- G9a histone methyltransferase contributes to imprinting in the mouse placenta.;Wagschal Alexandre, Sutherland Heidi G, Woodfine Kathryn, Henckel Amandine, Chebli Karim, Schulz Reiner, Oakey Rebecca J, Bickmore Wendy A, Feil Robert, ;2008;Molecular and cellular biology;28;1104-13; 18039842
- The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.;Nagano Takashi, Mitchell Jennifer A, Sanz Lionel A, Pauler Florian M, Ferguson-Smith Anne C, Feil Robert, Fraser Peter, ;2008;Science (New York, N.Y.);322;1717-20; 18988810