STOCK Fcamrtm1.2Jsv/Cnbc

Status

Available to order

EMMA IDEM:04667
Citation informationRRID:IMSR_EM:04667 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameSTOCK Fcamrtm1.2Jsv/Cnbc
Alternative nameFcamR (4D6)- Null
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFcamrtm1.2Jsv
Gene/Transgene symbolFcamr

Information from provider

ProviderSjef Verbeek
Provider affiliationHuman Genetics, Leiden University Medical Center (LUMC)
Genetic informationAnti-sense insertion in intron 3 of Neo selection marker flanked by Frt sites and 5' loxP. In addition, insertion of one loxP site in intron 4. By breeding to the EIIaCre deleter mouse line, the Neo selection marker and intron 4 were deleted to obtain the "FcamR-null" mouse.
Phenotypic informationIn the kidney, a 50% expression of the RNA coding for a soluble receptor is detected.
Breeding historyChimera crossed to EIIaCre deleter mouse. F1 crossed to C57BL/6. F2 intercrossed. Homozygous (cre recombinase negative) animals selected for further breeding.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos8-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal spleen germinal center morphology / MGI
  • abnormal somatic hypermutation frequency / MGI
  • abnormal memory B cell differentiation / MGI
  • abnormal marginal zone B cell physiology / MGI
  • abnormal follicular dendritic cell antigen presentation / MGI
  • increased spleen germinal center number / MGI
  • increased spleen germinal center size / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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