- hypoglycemia / MGI
- extramedullary hematopoiesis / MGI
- increased bone marrow cell number / MGI
- decreased cell proliferation / MGI
- abnormal mammary gland development / MGI
- abnormal branching of the mammary ductal tree / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- impaired ovarian folliculogenesis / MGI
- absent corpus luteum / MGI
- skin lesions / MGI
- decreased body weight / MGI
- abnormal osteoclast physiology / MGI
- increased circulating triglyceride level / MGI
- abnormal circulating free fatty acids level / MGI
- increased circulating corticosterone level / MGI
- decreased brown adipose tissue amount / MGI
- impaired macrophage phagocytosis / MGI
- abnormal humoral immune response / MGI
- abnormal lactation / MGI
- female infertility / MGI
- decreased incidence of induced tumors / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal lipid homeostasis / MGI
- abnormal definitive hematopoiesis / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node cortex morphology / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal lymph node secondary follicle morphology / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal lymph node medulla morphology / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal mucosa-associated lymphoid tissue morphology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal innate immunity / MGI
- abnormal cell-mediated immunity / MGI
- abnormal plasma cell morphology / MGI
- abnormal macrophage physiology / MGI
- increased IgG level / MGI
- granulomatous inflammation / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating free fatty acid level / MGI
- decreased glycogen catabolism rate / MGI
- decreased circulating insulin level / MGI
- enlarged submandibular lymph nodes / MGI
- glomerulonephritis / MGI
- increased insulin sensitivity / MGI
- abnormal brown adipose tissue morphology / MGI
- no phenotypic analysis / MGI
- calcified muscle / MGI
- decreased ovulation rate / MGI
- impaired luteinization / MGI
- impaired granulosa cell differentiation / MGI
- abnormal gluconeogenesis / MGI
- abnormal zygomatic arch morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- myositis / MGI
- abnormal thoracic cage morphology / MGI
- abnormal skeletal muscle mass / MGI
- abnormal osteoclast morphology / MGI
- decreased osteoclast cell number / MGI
- increased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- abnormal cell differentiation / MGI
- abnormal clavicle morphology / MGI
- decreased triglyceride level / MGI
- abnormal enzyme/coenzyme level / MGI
- reproductive system phenotype / MGI
- increased susceptibility to fungal infection / MGI
- decreased percent body fat/body weight / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal T-helper 2 physiology / MGI
- abnormal skeleton morphology / MGI
- decreased liver regeneration / MGI
- increased circulating glucose level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- hemosiderosis / MGI
- abnormal adipose tissue physiology / MGI
- decreased circulating leptin level / MGI
- impaired lipolysis / MGI
- abnormal osteoclast differentiation / MGI
- enlarged mesenteric lymph nodes / MGI
- abnormal spleen secondary B follicle morphology / MGI
- increased circulating interleukin-6 level / MGI
- decreased circulating interleukin-12 level / MGI
- increased interleukin-12 secretion / MGI
- decreased susceptibility to endotoxin shock / MGI
- abnormal tumor necrosis factor level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to induced cell death / MGI
- absent estrous cycle / MGI
- decreased gonadal fat pad weight / MGI
- decreased epididymal fat pad weight / MGI
- decreased uterine fat pad weight / MGI
- decreased trabecular bone thickness / MGI
- increased trabecular bone thickness / MGI
- decreased skeletal muscle fiber size / MGI
- skeletal muscle fibrosis / MGI
- abnormal mammary gland duct morphology / MGI
- increased keratinocyte apoptosis / MGI
- enlarged inguinal lymph nodes / MGI
- enlarged axillary lymph nodes / MGI
- abnormal mammary gland epithelium physiology / MGI
- abnormal bone trabecula morphology / MGI
- increased bone trabecula number / MGI
- decreased bone trabecula number / MGI
- increased bone volume / MGI
- decreased bone volume / MGI
- impaired adaptive thermogenesis / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal lymph node medullary cord morphology / MGI
- renal glomerulus hypertrophy / MGI
- expanded mesangial matrix / MGI
- mesangial cell hyperplasia / MGI
- decreased lipoprotein lipase activity / MGI
- abnormal brown adipose tissue physiology / MGI
- enhanced osteoblast differentiation / MGI
- impaired skeletal muscle regeneration / MGI
- increased bone ossification / MGI
- decreased bone ossification / MGI
- increased bone mineralization / MGI
- decreased bone mineralization / MGI
- increased muscle cell glucose uptake / MGI
STOCK Cebpbtm1.1Nord/Kctt
| Status | Available to order |
| EMMA ID | EM:04677 |
| Citation information | RRID:IMSR_EM:04677 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Cebpbtm1.1Nord/Kctt |
| Alternative name | Cebpbfl (ICER/129Sv/C57BL6) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cebpbtm1.1Nord |
| Gene/Transgene symbol | Cebpb |
Information from provider
| Provider | Magnus Nord |
| Provider affiliation | Dept of Medicine-Solna, Div f Respir Med, Karolinska Institutet |
| Additional owner | Dr. Lukas Didon, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, U.S.A. |
| Genetic information | Floxed Cebpb allele for conditional knockout. Neomycin expression cassette excised by mating with flp recombinase-expressing mice. |
| Phenotypic information | No phenotype observed in the absence of cre recombinase. |
| Breeding history | After standard generation in C57BL/6 x 129/Sv background, ICR has been introduced. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous males, wild-type C57BL/6J females |
| Breeding at archiving centre | No breeding at archiving centre. |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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