| Status | Available to order |
| EMMA ID | EM:00047 |
| Citation information | RRID:IMSR_EM:00047 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Cd3etm1Mal/Orl |
| Alternative name | CD3e° |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd3etm1Mal |
| Gene/Transgene symbol | Cd3e |
| Provider | M Malissen |
| Provider affiliation | U136, CIML |
| Genetic information | Mutant mice deficient in the Cd3e gene, obtained by mutation of the gene by homologous recombination (insertion of the neomycin-resistance gene into exon 5). |
| Phenotypic information | In the absence of intact CD3-epsilon subunit, the development of thymocytes appears to be arrested at the CD44-/low CD25+ triple-negative stage. CD3-epsilon deficient thymocytes do rearrange their T cell receptor (TCR) beta gene segments and produce low levels of TCR beta transcripts. |
| Breeding history | Bruce 4 ES cells; chimaeras crossed with C57BL/6. |
| References |
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| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous males, wild-type C57BL/6J females |
| Breeding at archiving centre | Embryos are at the 2-cells stage or 4-8 cells stage. |
Orphanet associated rare diseases, based on orthologous gene matching
