MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129S2-WwoxGt(W088C04)Wrst/Ieg
| Status | Available to order |
| EMMA ID | EM:04729 |
| Citation information | RRID:IMSR_EM:04729 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-WwoxGt(W088C04)Wrst/Ieg |
| Alternative name | W088C04 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | WwoxGt(W088C04)Wrst |
| Gene/Transgene symbol | Wwox |
Information from provider
| Provider | Jerzy Adamski |
| Provider affiliation | IEG, HMGU |
| Genetic information | Inactivation of the Wwox gene by integration of a lacZ cassette a the 3' end of intron 4-5. |
| Phenotypic information | Not yet characterised. |
| Breeding history | Backcrossed to C57BL/6 (5 generations), currently using heterozygous animals for breeding. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency / Orphanet_284282
- Undetermined early-onset epileptic encephalopathy / Orphanet_442835
- 46,XY partial gonadal dysgenesis / Orphanet_251510
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- hypoglycemia / MGI
- decreased circulating calcium level / MGI
- decreased leukocyte cell number / MGI
- enlarged spleen / MGI
- small spleen / MGI
- small ovary / MGI
- small testis / MGI
- Leydig cell hyperplasia / MGI
- small seminiferous tubules / MGI
- seminiferous tubule degeneration / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal osteoclast physiology / MGI
- increased circulating phosphate level / MGI
- abnormal circulating enzyme level / MGI
- anemia / MGI
- postnatal growth retardation / MGI
- abnormal homeostasis / MGI
- reduced male fertility / MGI
- testis hypoplasia / MGI
- neoplasm / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased B cell derived lymphoma incidence / MGI
- premature death / MGI
- abnormal skeleton development / MGI
- increased brain weight / MGI
- abnormal thymus cortex morphology / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating testosterone level / MGI
- decreased circulating alkaline phosphatase level / MGI
- no phenotypic analysis / MGI
- decreased circulating bicarbonate level / MGI
- increased circulating chloride level / MGI
- decreased circulating chloride level / MGI
- testicular atrophy / MGI
- decreased liver weight / MGI
- spleen atrophy / MGI
- increased osteosarcoma incidence / MGI
- abnormal compact bone morphology / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased spleen weight / MGI
- decreased thymus weight / MGI
- decreased osteoblast cell number / MGI
- increased bone resorption / MGI
- cachexia / MGI
- decreased circulating cholesterol level / MGI
- increased circulating bilirubin level / MGI
- growth/size/body region phenotype / MGI
- reproductive system phenotype / MGI
- decreased circulating serum albumin level / MGI
- abnormal skeleton morphology / MGI
- Leydig cell hypoplasia / MGI
- decreased circulating glucose level / MGI
- increased blood urea nitrogen level / MGI
- decreased circulating total protein level / MGI
- increased circulating potassium level / MGI
- decreased circulating aspartate transaminase level / MGI
- decreased circulating sodium level / MGI
- abnormal pituitary gland physiology / MGI
- increased lung tumor incidence / MGI
- abnormal osteoblast differentiation / MGI
- decreased survivor rate / MGI
- increased blood uric acid level / MGI
- increased pituitary gland weight / MGI
- thin uterine horn / MGI
- decreased trabecular bone thickness / MGI
- abnormal primary ovarian follicle morphology / MGI
- decreased theca cell number / MGI
- increased skeletal tumor incidence / MGI
- mortality/aging / MGI
- decreased bone trabecula number / MGI
- decreased trabecular bone volume / MGI
- decreased trabecular bone connectivity density / MGI
- decreased compact bone area / MGI
- postnatal lethality, complete penetrance / MGI
- increased adrenal gland weight / MGI