IMPC phenotypes (gene matching)
B6.CAnNCrl(C3)-Dync1i2m1H/H
| Status | Available to order |
| EMMA ID | EM:04731 |
| Citation information | RRID:IMSR_EM:04731 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.CAnNCrl(C3)-Dync1i2m1H/H |
| Alternative name | Dync1i2 T148I |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Dync1i2m1H |
| Gene/Transgene symbol | Dync1i2 |
Information from provider
| Provider | Elizabeth Fisher |
| Provider affiliation | Neurodegenerative Disease, UCL Institute of Neurology |
| Additional owner | From the MRC Harwell ENU mutagenesis program. |
| Genetic information | An ENU induced mutation causing a single base pair change in the cytoplasmic dynein intermediate chain 2 gene (Dync1i2) leading to an T to I amino acid substitution at position 172 (Genbank file GU992208); this is position 148 (T148I) in other splice isoforms. |
| Phenotypic information | Currently being tested, trend towards slight locomotor deficit, nothing significant so far. |
| Breeding history | Founder mouse came from the Harwell ENU program in which male BALB/cAnN mice were treated with ENU then crossed to C3H females. We took an F1 mouse and have backcrossed it for 9 or 10 generations to C57BL/6J animals so far. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6J males |
| Breeding at archiving centre | Males were archived by sperm freezing at the time of importation. No breeding was performed at the archiving centre. The males received for archiving were N9 or N10. |