| Status | Available to order |
| EMMA ID | EM:04769 |
| Citation information | RRID:IMSR_EM:04769 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tyrc-em/Cnbc |
| Alternative name | Tyr |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Tyrc-em, Tyrc |
| Gene/Transgene symbol | Tyr, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Additional owner | The original Tyrc-em extreme dilution mottled allele is kept at MRC-Harwell, FESA. Person of contact: Martin Fray |
| Genetic information | Mice carrying the Tyrc-em "extreme dilution mottled" allele were imported as live animals from MRC Harwell (FESA, Peter Glenister) in 2001 after rescuing the line from frozen embryos. Genotype received included: Tyrc-em/Tyr+. Since then they were bred to albino outbred Hsd:NMRI mice and eventually maintained as homozygous Tyrc-em/Tyrc-em. The Tyrc-em allele is a mutation that occurred in the Tyrc-m stock. The molecular basis was established in 2005, by the laboratory of Lluis Montoliu (Lavado et al. 2005 JBC). |
| Phenotypic information | Tyrc-em "extreme dilution mottled" mice have a pale almost-albino coat, with some pigmentation in ears, and ruby eyes. Homozygous are darker (more pigmented) than heterozygous, which appear to be almost-albino, with the exception of a somewhat "dirty white" coat colour. |
| Breeding history | Since 2001, the Tyrc-em extreme dilution mottled allele has been bred and maintained, as homozygous, in albino outbred Hsd:NMRI mouse strain. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous NMRI males, wild-type NMRI females |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
