MGI phenotypes (allele matching)
- behavior/neurological phenotype / MGI
B6;D2-Tg(Eno2-MFN2)L916Ugfm/Orl
| Status | Available to order |
| EMMA ID | EM:04782 |
| Citation information | RRID:IMSR_EM:04782 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;D2-Tg(Eno2-MFN2)L916Ugfm/Orl |
| Alternative name | MitoCharc0 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Eno2-MFN2)L916Ugfm |
| Gene/Transgene symbol | Tg(Eno2-MFN2)L916Ugfm |
Information from provider
| Provider | Romain Cartoni |
| Provider affiliation | F.M. Kirby Neurobiology Center , Children |
| Genetic information | The MitoCharc0 transgene was designed with the human mitofusin 2 (MNF2) gene driven by a neuron specific enolase promoter. The transgene was microinjected into fertilized C57BL/6 x DBA/2 F1 oocytes, and founder mice were bred to C57BL/6J mice to establish a colony. |
| Phenotypic information | MitoCharc0 transgenic mice display no obvious phenotypes. This strain was generated as a control of the two mutant strains MitoCharc1 and 2. |
| Breeding history | Founders with the mixed background C57BL/6 x B6D2F1 were first bred with pure C57BL/6. Transgenic hemizygotes were bred with non-Tg mice from these breedings. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- behavior/neurological phenotype / MGI
Literature references
- Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.;Cartoni Romain, Arnaud Estelle, Médard Jean-Jacques, Poirot Olivier, Courvoisier Delphine S, Chrast Roman, Martinou Jean-Claude, ;2010;Brain : a journal of neurology;133;1460-9; 20418531