B6;129P2-Ifitm3^tm1Masu/Cnbc

Status	Available to order
EMMA ID	EM:04805
Citation information	RRID:IMSR_EM:04805 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129P2-Ifitm3^tm1Masu/Cnbc
Alternative name	Ifitm3EGFP
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Ifitm3^tm1Masu
Gene/Transgene symbol	Ifitm3

Information from provider

Provider	David Adams
Provider affiliation	Sanger Cryopreservation Unit, Wellcome Trust Sanger Institute
Genetic information	An EGFP knockin into the Ifitm3 locus. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA. Mol Cell Biol. 2008 Aug;28(15):4688-96. PMID: 18505827
Phenotypic information	Normal, viable.
Breeding history	IVC in an SPF facility.
References	Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.;Lange Ulrike C, Adams David J, Lee Caroline, Barton Sheila, Schneider Robert, Bradley Allan, Surani M Azim, ;2008;Molecular and cellular biology;28;4688-96; 18505827 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.;Brass Abraham L, Huang I-Chueh, Benita Yair, John Sinu P, Krishnan Manoj N, Feeley Eric M, Ryan Bethany J, Weyer Jessica L, van der Weyden Louise, Fikrig Erol, Adams David J, Xavier Ramnik J, Farzan Michael, Elledge Stephen J, ;2009;Cell;139;1243-54; 20064371 Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)

increased susceptibility to viral infection / MGI
embryo phenotype / MGI
reproductive system phenotype / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI

MGI phenotypes (gene matching)

increased susceptibility to viral infection / MGI
no phenotypic analysis / MGI
embryo phenotype / MGI
reproductive system phenotype / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI

Literature references

Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.;Lange Ulrike C, Adams David J, Lee Caroline, Barton Sheila, Schneider Robert, Bradley Allan, Surani M Azim, ;2008;Molecular and cellular biology;28;4688-96; 18505827
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.;Brass Abraham L, Huang I-Chueh, Benita Yair, John Sinu P, Krishnan Manoj N, Feeley Eric M, Ryan Bethany J, Weyer Jessica L, van der Weyden Louise, Fikrig Erol, Adams David J, Xavier Ramnik J, Farzan Michael, Elledge Stephen J, ;2009;Cell;139;1243-54; 20064371
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.

B6;129P2-Ifitm3tm1Masu/Cnbc