MSOSLOW/Orl
| Status | Available to order |
| EMMA ID | EM:04845 |
| Citation information | RRID:IMSR_EM:04845 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | MSOSLOW/Orl |
| Alternative name | MSO-Slow |
| Strain type | Spontaneous |
| Allele/Transgene symbol | MSO-Slow |
| Gene/Transgene symbol | MSO-Slow |
Information from provider
| Provider | Jean-François Cloix |
| Provider affiliation | Neurobiology Laboratory, University of Orleans |
| Genetic information | Genetic selection of MSO-Slow mice based upon their very long latency toward seizures by injection of a single dose of 75 mg/kg methionine sulfoximine. The selection was performed on genetic random crosses of eight inbred mouse strains: ABP/Le, A/J, BALB/c, C3H/HeJ, C57BL/6J, CBA/H, DBA/2J and SWXL-4. |
| Phenotypic information | MSO-Slow line is characterized by 1) a very long latency and a very low susceptibility toward seizures upon injection of methionine sulfoximine; 2) low susceptibility to kainic acid and MK-801; 3) an increase in brain glycogen content induced by methionine sulfoximine; 4) involvement of 5-HT in seizures and brain glycogen content. This line has its counterpart as the MSO-Fast mice. |
| Breeding history | Random crosses of eight inbred mouse strains: ABP/Le, A/J, BALB/c, C3H/HeJ, C57BL/6J, CBA/H, DBA/2J and SWXL-4 to generate G1. G1 was challenged by a single ip injection of 75 mg/kg methionine sulfoximine and selected upon latency to methionine sulfoximine induced seizures. Mice having the longest latency were inter-crossed without brother-sister crosses. This challenge was repeated for 10 generations, reaching the point where the phenotype was considered as fixed. Then crossing sisters with brothers for 8 generations to perform inbreeding. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous males, homozygous females |
| Breeding at archiving centre | Strain with no genotyping |
Literature references
- Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.;Cloix Jean-François, Tahi Zahir, Martin Benoît, Hévor Tobias, ;2010;Epilepsia;51;118-28; 20015245