IMPC phenotypes (allele matching)
CD1.129-Nodaltm1Rob/Orl
| Status | Available to order |
| EMMA ID | EM:04858 |
| Citation information | RRID:IMSR_EM:04858 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CD1.129-Nodaltm1Rob/Orl |
| Alternative name | 129 Nodal-LacZ (KO) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nodaltm1Rob |
| Gene/Transgene symbol | Nodal |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | CNRS UMR7592 Universite Paris 6 et 7, Institut Jacques Monod |
| Additional owner | Dr. Jerome Collignon, Institut Jacques Monod, Paris, France |
| Genetic information | Insertion of IRES-betaGeob (beta-galactosidase + neomycin resistance) into the second exon of the Nodal gene. |
| Phenotypic information | Mutant embryos fail to gastrulate and die at E8.0. |
| Breeding history | This mutation was first generated and maintained on a 129 background before being backcrossed and maintained on a CD1 background (N>10). |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous CD-1 males, wild-type CD-1 females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Situs inversus totalis / Orphanet_101063
- Alobar holoprosencephaly / Orphanet_93925
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
IMPC phenotypes (gene matching)
- corneal vascularization / IMPC
- preweaning lethality, complete penetrance / IMPC
- increased circulating HDL cholesterol level / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
- decreased locomotor activity / IMPC
- increased grip strength / IMPC
- increased circulating triglyceride level / IMPC
- abnormal startle reflex / IMPC
- increased large unstained cell number / IMPC
- increased circulating cholesterol level / IMPC
MGI phenotypes (allele matching)
- decreased embryo size / MGI
- embryonic growth arrest / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- prenatal lethality, complete penetrance / MGI
- abnormal heart looping / MGI
- absent notochord / MGI
- abnormal gastrulation / MGI
- abnormal gastrulation movements / MGI
- abnormal primitive node morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal visceral endoderm morphology / MGI
- fused somites / MGI
- embryonic-extraembryonic boundary constriction / MGI
MGI phenotypes (gene matching)
- abnormal heart development / MGI
- abnormal heart looping / MGI
- abnormal interventricular septum morphology / MGI
- enlarged pericardium / MGI
- trabecula carnea hypoplasia / MGI
- abnormal foregut morphology / MGI
- right-sided isomerism / MGI
- right pulmonary isomerism / MGI
- abnormal liver morphology / MGI
- small liver / MGI
- pale liver / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal brain development / MGI
- absent floor plate / MGI
- absent notochord / MGI
- decreased body size / MGI
- abnormal ectoderm development / MGI
- failure of primitive streak formation / MGI
- abnormal gastrulation / MGI
- decreased embryo size / MGI
- abnormal embryo turning / MGI
- abnormal left-right axis patterning / MGI
- absent amniotic folds / MGI
- embryonic growth arrest / MGI
- pericardial edema / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal gastrulation movements / MGI
- abnormal primitive streak formation / MGI
- abnormal primitive streak morphology / MGI
- small ectoplacental cone / MGI
- situs ambiguus / MGI
- aortic hypertrophy / MGI
- no phenotypic analysis / MGI
- absent allantois / MGI
- abnormal digestive system development / MGI
- absent placental labyrinth / MGI
- abnormal craniofacial development / MGI
- thin myocardium compact layer / MGI
- abnormal primitive node morphology / MGI
- transposition of great arteries / MGI
- heterotaxia / MGI
- abnormal direction of heart looping / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- abnormal prechordal plate morphology / MGI
- absent prechordal plate / MGI
- truncated notochord / MGI
- abnormal neural fold formation / MGI
- absent amnion / MGI
- holoprosencephaly / MGI
- abnormal rostral-caudal axis patterning / MGI
- embryo phenotype / MGI
- right atrial isomerism / MGI
- abnormal heart position or orientation / MGI
- abnormal extraembryonic mesoderm development / MGI
- absent somites / MGI
- abnormal anterior visceral endoderm morphology / MGI
- abnormal hindgut morphology / MGI
- abnormal mesendoderm development / MGI
- absent primitive node / MGI
- increased trophoblast giant cell number / MGI
- abnormal lateral plate mesoderm morphology / MGI
- atrial septal defect / MGI
- common atrium / MGI
- abnormal extraembryonic ectoderm morphology / MGI
- abnormal stomach position or orientation / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- abnormal visceral endoderm morphology / MGI
- abnormal parietal yolk sac morphology / MGI
- absent visceral yolk sac / MGI
- thin placenta labyrinth / MGI
- fused somites / MGI
- absent heart tube / MGI
- delayed heart development / MGI
- absent foregut / MGI
- truncated foregut / MGI
- absent midbrain / MGI
- increased spongiotrophoblast size / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral body truncation / MGI
- abnormal head development / MGI
- abnormal heart apex morphology / MGI
- decreased embryonic neuroepithelial cell proliferation / MGI
- absent head fold / MGI
Literature references
- A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.;Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow P N, Lovell-Badge R, ;1996;Development (Cambridge, England);122;509-20; 8625802
- Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo.;Camus Anne, Perea-Gomez Aitana, Moreau Anne, Collignon Jérôme, ;2006;Developmental biology;295;743-55; 16678814
- Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.;Mesnard Daniel, Guzman-Ayala Marcela, Constam Daniel B, ;2006;Development (Cambridge, England);133;2497-505; 16728477