B6;129P2-Klhl6tm1Btoci/Orl

Status

Available to order

EMMA IDEM:04904
Citation informationRRID:IMSR_EM:04904 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6;129P2-Klhl6tm1Btoci/Orl
Alternative nameKLHL6 knock-out
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolKlhl6tm1Btoci
Gene/Transgene symbolKlhl6

Information from provider

ProviderBarbara Bertocci
Provider affiliationINSERM 783 ex373
Genetic informationThe Klhl6 deficient strain has been obtained by deletion of exon1 (replaced by neomycin gene).
Phenotypic informationDeficiency of mature B cells.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivinghomozygous C57BL/6J males, wild-type C57BL/6J females
Breeding at archiving centrestrain with no genotyping protocol

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal testis morphology / IMPC
  • abnormal thymus morphology / IMPC
  • small seminal vesicle / IMPC
  • abnormal heart morphology / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged thymus / IMPC
  • enlarged heart / IMPC
  • abnormal pancreas morphology / IMPC
  • increased T cell number / IMPC
  • abnormal lung morphology / IMPC
  • abnormal kidney morphology / IMPC
  • enlarged kidney / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • abnormal inspiratory capacity / IMPC
  • decreased eosinophil cell number / IMPC
  • small spleen / IMPC
  • small testis / IMPC
  • increased T-helper cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • enlarged pancreas / IMPC
MGI phenotypes (gene matching)
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • abnormal B cell differentiation / MGI
  • abnormal adaptive immunity / MGI
  • decreased spleen weight / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased single-positive T cell number / MGI
  • increased B-1b cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • abnormal lymph node germinal center morphology / MGI
  • decreased central memory CD4-positive, alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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