MGI phenotypes (allele matching)
- osteoporosis / MGI
B6.129-Mchr1tm1Ohl/Kctt
| Status | Available to order |
| EMMA ID | EM:04912 |
| Citation information | RRID:IMSR_EM:04912 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Mchr1tm1Ohl/Kctt |
| Alternative name | B6.129-MCHr1 tm1AZTC |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mchr1tm1Ohl |
| Gene/Transgene symbol | Mchr1 |
Information from provider
| Provider | Mohammad Bohlooly |
| Provider affiliation | ATCG, AstraZeneca R&D |
| Genetic information | Mice lacking the rodent MCH receptor (Mchr1 -/- mice). |
| Phenotypic information | The mice have a lean phenotype and are resistant to diet-induced obesity. Increased energy expenditure appears to be an important factor because Mchr1 -/- mice show a slight increase in food consumption. We also demonstrate that: - the absence of a functional Mchr1 system leads to an increased basal heart rate independent of increased locomotor activity and this appears to be caused by increased sympathetic and decreased parasympathetic activity compared with wild-type animals; - under fasting conditions Mchr1 -/- mice maintain heart rate and body temperature for longer than wild-type mice before the initiation of transient but profound drops in these two parameters, a response normally involving reduced sympathetic activity. It thus appears that the Mchr1 system is involved in both the tonic regulation of autonomic activity and the fast-induced autonomic suppression of heart rate and body temperature. |
| Breeding history | The strain is bred on C57BL/6 in a het x wt colony. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous males, wild-type C57BL/6N females |
| Breeding at archiving centre | No breeding |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- osteoporosis / MGI
- decreased body weight / MGI
- weight loss / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- polyphagia / MGI
- abnormal sleep pattern / MGI
- increased circulating corticosterone level / MGI
- abnormal nervous system electrophysiology / MGI
- increased heart rate / MGI
- decreased circulating insulin level / MGI
- abnormal passive avoidance behavior / MGI
- abnormal frequency of paradoxical sleep / MGI
- abnormal hormone level / MGI
- increased lean body mass / MGI
- abnormal metabolism / MGI
- homeostasis/metabolism phenotype / MGI
- abnormal energy expenditure / MGI
- decreased percent body fat/body weight / MGI
- decreased thyroxine level / MGI
- increased body temperature / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- slow postnatal weight gain / MGI
- impaired behavioral response to xenobiotic / MGI
- decreased total body fat amount / MGI
- decreased serotonin level / MGI
- decreased response to stress-induced hyperthermia / MGI
- decreased respiratory quotient / MGI
- abnormal circadian temperature homeostasis / MGI
- increased food intake / MGI
- increased fluid intake / MGI
Literature references
- Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity.;Astrand Annika, Bohlooly-Y Mohammad, Larsdotter Sara, Mahlapuu Margit, Andersén Harriet, Tornell Jan, Ohlsson Claes, Snaith Mike, Morgan David G A, ;2004;American journal of physiology. Regulatory, integrative and comparative physiology;287;R749-58; 15130877
- Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin.;Bjursell Mikael, Egecioglu Emil, Gerdin Anna-Karin, Svensson Lennart, Oscarsson Jan, Morgan David, Snaith Michael, Törnell Jan, Bohlooly-Y Mohammad, ;2005;Biochemical and biophysical research communications;326;759-65; 15607734