IMPC phenotypes (gene matching)
B6;129-Fshrtm1Mha/H
| Status | Available to order |
| EMMA ID | EM:04913 |
| Citation information | RRID:IMSR_EM:04913 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Fshrtm1Mha/H |
| Alternative name | FSHRKO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Fshrtm1Mha |
| Gene/Transgene symbol | Fshr |
Information from provider
| Provider | Margaret Abel |
| Provider affiliation | University of Oxford |
| Genetic information | Deletion of exon one of follicle stimulating hormone receptor (Fshr) gene. |
| Phenotypic information | Males are fertile, testis weight reduced; females are infertile, ovulation does not occur. |
| Breeding history | Inbred. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous males |
| Breeding at archiving centre | No breeding performed at archiving centre. Males were archived upon arrival from the depositor. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- 46,XX gonadal dysgenesis / Orphanet_243
MGI phenotypes (allele matching)
- abnormal ovary morphology / MGI
- small ovary / MGI
- impaired ovarian folliculogenesis / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- vagina atresia / MGI
- small seminiferous tubules / MGI
- increased circulating follicle stimulating hormone level / MGI
- increased circulating luteinizing hormone level / MGI
- female infertility / MGI
- abnormal testes secretion / MGI
- abnormal ovarian secretion / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- uterus atrophy / MGI
- decreased uterus weight / MGI
- increased follicle stimulating hormone level / MGI
- absent estrous cycle / MGI
MGI phenotypes (gene matching)
- abnormal abdominal fat pad morphology / MGI
- decreased bone mineral density / MGI
- kyphosis / MGI
- enlarged spleen / MGI
- hippocampal neuron degeneration / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal uterus morphology / MGI
- abnormal ovary morphology / MGI
- small ovary / MGI
- impaired ovarian folliculogenesis / MGI
- abnormal ovarian folliculogenesis / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- abnormal vagina orifice morphology / MGI
- vagina atresia / MGI
- small testis / MGI
- small seminiferous tubules / MGI
- abnormal spermatogenesis / MGI
- small seminal vesicle / MGI
- increased body weight / MGI
- obese / MGI
- weight loss / MGI
- increased anxiety-related response / MGI
- hunched posture / MGI
- anemia / MGI
- increased circulating follicle stimulating hormone level / MGI
- increased circulating luteinizing hormone level / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- abnormal spermiogenesis / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- ovary cysts / MGI
- abnormal seminiferous tubule morphology / MGI
- neurodegeneration / MGI
- long gestation period / MGI
- abnormal epididymis morphology / MGI
- small uterus / MGI
- abnormal caput epididymis morphology / MGI
- abnormal corpus epididymis morphology / MGI
- asthenozoospermia / MGI
- increased follicle recruitment / MGI
- abnormal spermatogonia proliferation / MGI
- oligozoospermia / MGI
- absent ovarian follicles / MGI
- decreased circulating testosterone level / MGI
- increased circulating testosterone level / MGI
- abnormal testes secretion / MGI
- abnormal ovarian secretion / MGI
- increased thigmotaxis / MGI
- abnormal thoracic vertebrae morphology / MGI
- increased pre-B cell number / MGI
- calcinosis / MGI
- astrocytosis / MGI
- abnormal ovary physiology / MGI
- enlarged clitoris / MGI
- increased ovarian carcinoma incidence / MGI
- pallor / MGI
- premature aging / MGI
- abnormal testis development / MGI
- abnormal uterine environment / MGI
- abnormal sperm physiology / MGI
- absent oocytes / MGI
- ovary atrophy / MGI
- ovary hemorrhage / MGI
- abnormal testis size / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- uterus atrophy / MGI
- vagina atrophy / MGI
- uterine hemorrhage / MGI
- increased uterus weight / MGI
- decreased uterus weight / MGI
- enlarged uterus / MGI
- decreased seminal vesicle weight / MGI
- decreased epididymis weight / MGI
- small epididymis / MGI
- abnormal epididymis epithelium morphology / MGI
- abnormal thrombosis / MGI
- increased follicle stimulating hormone level / MGI
- increased luteinizing hormone level / MGI
- cachexia / MGI
- decreased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- Sertoli cell hypoplasia / MGI
- teratozoospermia / MGI
- abnormal enzyme/coenzyme activity / MGI
- increased apoptosis / MGI
- abnormal female germ cell morphology / MGI
- abnormal male germ cell morphology / MGI
- abnormal spermatogonia morphology / MGI
- abnormal spermatid morphology / MGI
- increased ovary tumor incidence / MGI
- increased gonadotroph cell number / MGI
- increased thyrotroph cell number / MGI
- abnormal granulosa cell morphology / MGI
- anovulation / MGI
- abnormal ovarian follicle number / MGI
- abnormal sperm flagellum morphology / MGI
- increased total fat pad weight / MGI
- delayed male fertility / MGI
- delayed female fertility / MGI
- decreased vagina weight / MGI
- early vaginal opening / MGI
- early reproductive senescence / MGI
- prolonged estrous cycle / MGI
- absent estrous cycle / MGI
- prolonged diestrus / MGI
- abnormal estrus / MGI
- thin uterus / MGI
- uterus cysts / MGI
- myometrium hypoplasia / MGI
- oocyte degeneration / MGI
- abnormal endometrial gland morphology / MGI
- uterus adenomyosis / MGI
- increased uterus tumor incidence / MGI
- abnormal sperm head morphology / MGI
- detached acrosome / MGI
- abnormal sperm nucleus morphology / MGI
- enlarged sperm head / MGI
- kinked sperm flagellum / MGI
- small caput epididymis / MGI
- enlarged endometrial glands / MGI
- polyovular ovarian follicle / MGI
- abnormal sperm axoneme morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- decreased primary ovarian follicle number / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- adenohypophysis hyperplasia / MGI
- decreased femur weight / MGI
Literature references
- The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction.;Abel M H, Wootton A N, Wilkins V, Huhtaniemi I, Knight P G, Charlton H M, ;2000;Endocrinology;141;1795-803; 10803590