B6.FVB-Tg(CEPHY152F7)12Hgc/Orl
| Status | Available to order |
| EMMA ID | EM:04932 |
| Citation information | RRID:IMSR_EM:04932 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.FVB-Tg(CEPHY152F7)12Hgc/Orl |
| Alternative name | YAC Lg12 (B6j) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CEPHY152F7)12Hgc |
| Gene/Transgene symbol | Tg(CEPHY152F7)12Hgc |
Information from provider
| Provider | Jean Maurice Delabar |
| Provider affiliation | EA3508- IFR117- Univ Paris7 |
| Genetic information | Transgenic for the human YAC 152F7 (Chromosome 21). This line is congenic of the initial YAC Lg 12 on FVB background. |
| Phenotypic information | Increased brain size. Learning impairment. |
| Breeding history | Outcrossed on C57BL/6J: N=10 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Breeding at archiving centre | transgenic males |
Literature references
- Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.;Sebrié Catherine, Chabert Caroline, Ledru Aurélie, Guedj Fayçal, Po Chrystelle, Smith Desmond J, Rubin Edward, Rivals Isabelle, Beloeil Jean-Claude, Gillet Brigitte, Delabar Jean-Maurice, ;2008;Anatomical record (Hoboken, N.J. : 2007);291;254-62; 18231969
- The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.;Laguna Ariadna, Aranda Sergi, Barallobre María José, Barhoum Rima, Fernández Eduardo, Fotaki Vassiliki, Delabar Jean Maurice, de la Luna Susana, de la Villa Pedro, Arbonés Maria L, ;2008;Developmental cell;15;841-53; 19081073