B6.Cg-Enpp2tm1Vart/Flmg

Status

Available to order

EMMA IDEM:04967
Citation informationRRID:IMSR_EM:04967 

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International strain nameB6.Cg-Enpp2tm1Vart/Flmg
Alternative nameC57BL/6-Enpp2tm1Vart/Flmg
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolEnpp2tm1Vart
Gene/Transgene symbolEnpp2

Information from provider

ProviderVassilis Aidinis
Provider affiliationInstitute of Immunology, B.S.R.C. Al. Fleming
Genetic informationA loxP-flanked neomycin selection cassette has been inserted immediately upstream of exon 1. A third loxP site has been engineered immediately downstream of exon 2. Expression of cre recombinase in mice bearing this allele results in the excision of both exons and the selection cassette or, less frequently, in the excision of either the exons or the selection cassette.
Phenotypic informationNo abnormal phenotype detected.
References
  • ATX expression and LPA signalling are vital for the development of the nervous system.;Fotopoulou Stella, Oikonomou Nikos, Grigorieva Elena, Nikitopoulou Ioanna, Paparountas Triantafillos, Thanassopoulou Artemis, Zhao Zhenwen, Xu Yan, Kontoyiannis Dimitris L, Remboutsika Eumorphia, Aidinis Vassilis, ;2010;Developmental biology;339;451-64; 20079728
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivinghomozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos8-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal vasculogenesis / MGI
  • irregular heartbeat / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • absent vitelline blood vessels / MGI
  • abnormal allantois morphology / MGI
  • edema / MGI
  • abnormal blood circulation / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • no phenotypic analysis / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal forebrain development / MGI
  • kinked neural tube / MGI
  • abnormal axon extension / MGI
  • embryonic growth retardation / MGI
  • failure of initiation of embryo turning / MGI
  • dilated allantois / MGI
  • abnormal chorionic plate morphology / MGI
  • abnormal trophoblast giant cell morphology / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased circulating interleukin-6 level / MGI
  • abnormal chemokine level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • failure of chorioallantoic fusion / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • increased neural tube apoptosis / MGI
  • abnormal visceral yolk sac endoderm morphology / MGI

Literature references

  • ATX expression and LPA signalling are vital for the development of the nervous system.;Fotopoulou Stella, Oikonomou Nikos, Grigorieva Elena, Nikitopoulou Ioanna, Paparountas Triantafillos, Thanassopoulou Artemis, Zhao Zhenwen, Xu Yan, Kontoyiannis Dimitris L, Remboutsika Eumorphia, Aidinis Vassilis, ;2010;Developmental biology;339;451-64; 20079728

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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