MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
129-Acaa1btm1Vnf/Orl
| Status | Available to order |
| EMMA ID | EM:05001 |
| Citation information | RRID:IMSR_EM:05001 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Acaa1btm1Vnf/Orl |
| Alternative name | 129 sv ThB -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Acaa1btm1Vnf |
| Gene/Transgene symbol | Acaa1b |
Information from provider
| Provider | Valerie Nicolas-Frances |
| Provider affiliation | Laboratoire de Biochimie Metabolique et Nutritionnelle, University of Burgundy |
| Genetic information | The mouse peroxisomal thiolase B (acetyl-Coenzyme A acyltransferase 1B; Acaa1b) gene has been disrupted by homologous recombination between exon 2 and intron 3. |
| Phenotypic information | The mice are viable, fertile and healthy at birth. The peroxisomal fatty acids beta oxidation is reduced by 30% after Wy14,643 treatment (in comparison with wild-type mice). |
| Breeding history | Embryos are frozen by Charles Rivers. As I stop this work, I search for a solution to maintain this strain for the scientific world. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous 129/Sv males, wild-type 129/Sv females |
Disease and phenotype information
Literature references
- Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643.;Arnauld Ségolène, Fidaleo Marco, Clémencet Marie-Claude, Chevillard Grégory, Athias Anne, Gresti Joseph, Wanders Ronald J, Latruffe Norbert, Nicolas-Francès Valérie, Mandard Stéphane, ;2009;Biochimie;91;1376-86; 19772884
- Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism.;Chevillard Grégory, Clémencet Marie-Claude, Latruffe Norbert, Nicolas-Francès Valérie, ;2004;Biochimie;86;849-56; 15589695