IMPC phenotypes (allele matching)
- preweaning lethality, incomplete penetrance / IMPC
CBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:05013 |
| Citation information | RRID:IMSR_EM:05013 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc |
| Alternative name | Prkab1 genetrap |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Prkab1Gt(RRR454)Byg |
| Gene/Transgene symbol | Prkab1 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | The line was generated from the BayGenomics ES cell RRR454. |
| Phenotypic information | Homozygotes tend to die before weaning. Minor phenotypic defects in heterozygotes. |
| Breeding history | The chimaeras were generated from 129P2/OlaHsd ES cells, then crossed to CBA/Ca and intercrossed since. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
IMPC phenotypes (gene matching)
- decreased fasting circulating glucose level / IMPC
- decreased hematocrit / IMPC
- increased memory-marker gamma-delta T cell number / IMPC
- enlarged spleen / IMPC
- decreased grip strength / IMPC
- increased glycosylated hemoglobin level / IMPC
- decreased mean corpuscular volume / IMPC
- decreased hemoglobin content / IMPC
- decreased total retina thickness / IMPC
- hyperplasia / IMPC
- increased spleen weight / IMPC
- absent pinna reflex / IMPC
- enlarged heart / IMPC
- abnormal spleen morphology / IMPC
- impaired glucose tolerance / IMPC
- enlarged testis / IMPC
- increased memory-marker CD4-negative NK T cell number / IMPC
- abnormal epididymis morphology / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- decreased circulating cholesterol level / IMPC
- increased red blood cell distribution width / IMPC
- abnormal thymus morphology / IMPC
- decreased Ly6C-positive mature NK cell number / IMPC
- abnormal response to new environment / IMPC
- increased fasting circulating glucose level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- increased heart weight / IMPC
- decreased circulating phosphate level / IMPC
- decreased erythrocyte cell number / IMPC
- abnormal retina blood vessel morphology / IMPC
- decreased circulating amylase level / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- fibro-osseous lesion / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- shortened RR interval / IMPC
- enlarged epididymis / IMPC
- increased circulating bilirubin level / IMPC
- cataract / IMPC
- increased neutrophil cell number / IMPC
- abnormal heart left ventricle morphology / IMPC
- abnormal heart morphology / IMPC
- abnormal freezing behavior / IMPC
- abnormal retina inner nuclear layer morphology / IMPC
- decreased circulating LDL cholesterol level / IMPC
- abnormal lens morphology / IMPC
- enlarged kidney / IMPC
- increased circulating alkaline phosphatase level / IMPC
- impaired contextual conditioning behavior / IMPC
- decreased circulating iron level / IMPC
- abnormal kidney morphology / IMPC
- no spontaneous movement / IMPC
- decreased lymphocyte cell number / IMPC
- abnormal retina vasculature morphology / IMPC
- increased mean platelet volume / IMPC
- enlarged thymus / IMPC
- decreased body weight / IMPC
- decreased circulating chloride level / IMPC
- increased lung compliance / IMPC
- abnormal retina blood vessel pattern / IMPC
- decreased kidney weight / IMPC
- decreased bone mineral density / IMPC
- decreased lung elastance / IMPC
- increased heart rate / IMPC
- decreased bone mineral content / IMPC
- abnormal testis morphology / IMPC
- anophthalmia / IMPC
- increased circulating alanine transaminase level / IMPC
MGI phenotypes (allele matching)
- tremors / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal cerebellum morphology / MGI
- absent cerebellar granule layer / MGI
- abnormal myelination / MGI
- decreased body weight / MGI
- abnormal optic nerve morphology / MGI
- ataxia / MGI
- seizures / MGI
- abnormal astrocyte morphology / MGI
- loss of hippocampal neurons / MGI
- astrocytosis / MGI
- abnormal neuronal precursor proliferation / MGI
- abnormal axon morphology / MGI
- optic nerve hypoplasia / MGI
- brain vacuoles / MGI
- abnormal dendrite morphology / MGI
- slow postnatal weight gain / MGI
- decreased cerebellar granule cell number / MGI
- decreased neuron number / MGI
- decreased oligodendrocyte number / MGI
- abnormal neuron differentiation / MGI
- postnatal lethality, complete penetrance / MGI
- cerebellum atrophy / MGI
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- echinocytosis / MGI
- schistocytosis / MGI
- enlarged spleen / MGI
- tremors / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal cerebellum morphology / MGI
- absent cerebellar granule layer / MGI
- abnormal myelination / MGI
- decreased body weight / MGI
- abnormal optic nerve morphology / MGI
- ataxia / MGI
- abnormal lipid level / MGI
- hemolytic anemia / MGI
- seizures / MGI
- no abnormal phenotype detected / MGI
- abnormal astrocyte morphology / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal bone marrow morphology / MGI
- abnormal erythrocyte morphology / MGI
- increased mean platelet volume / MGI
- reticulocytosis / MGI
- anisocytosis / MGI
- decreased circulating insulin level / MGI
- microcytic anemia / MGI
- microcytosis / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- increased erythroid progenitor cell number / MGI
- loss of hippocampal neurons / MGI
- astrocytosis / MGI
- abnormal erythrocyte osmotic lysis / MGI
- decreased circulating iron level / MGI
- abnormal neuronal precursor proliferation / MGI
- increased spleen weight / MGI
- increased circulating bilirubin level / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- abnormal axon morphology / MGI
- decreased mean corpuscular hemoglobin / MGI
- decreased mean corpuscular hemoglobin concentration / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- abnormal inferior vena cava morphology / MGI
- optic nerve hypoplasia / MGI
- brain vacuoles / MGI
- abnormal dendrite morphology / MGI
- increased spleen red pulp amount / MGI
- slow postnatal weight gain / MGI
- decreased circulating interleukin-6 level / MGI
- increased spleen iron level / MGI
- decreased cerebellar granule cell number / MGI
- decreased neuron number / MGI
- decreased epididymal fat pad weight / MGI
- decreased liver triglyceride level / MGI
- decreased oligodendrocyte number / MGI
- abnormal neuron differentiation / MGI
- increased red blood cell distribution width / MGI
- stomatocytosis / MGI
- abnormal hepatocyte physiology / MGI
- decreased circulating magnesium level / MGI
- acanthocytosis / MGI
- postnatal lethality, complete penetrance / MGI
- increased erythroblast number / MGI
- increased circulating erythropoietin level / MGI
- increased circulating ferritin level / MGI
- abnormal reticulocyte cell number / MGI
- decreased food intake / MGI
- abnormal ductus venosus morphology / MGI
- cerebellum atrophy / MGI