STOCK Sox2ysb/WtsiCnbc[cc]

Status

Available to order

EMMA IDEM:05015
Citation informationRRID:IMSR_EM:05015 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameSTOCK Sox2ysb/WtsiCnbc[cc]
Alternative nameYellow submarine
Strain typeTransgenic Strains
Allele/Transgene symbolSox2ysb
Gene/Transgene symbolSox2

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerKathryn S E Cheah, University of Hong Kong
Genetic informationAn insertional mutation affecting inner ear and coat expression of Sox2.
Phenotypic informationHomozygotes show head bobbing, circling and deafness and have slightly yellow coats.
Breeding historyIntroduced on a mixed genetic background and kept within a closed colony for more than ten years.
References
  • Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.;Schraders Margit, Lee Kwanghyuk, Oostrik Jaap, Huygen Patrick L M, Ali Ghazanfar, Hoefsloot Lies H, Veltman Joris A, Cremers Frans P M, Basit Sulman, Ansar Muhammad, Cremers Cor W R J, Kunst Henricus P M, Ahmad Wasim, Admiraal Ronald J C, Leal Suzanne M, Kremer Hannie, ;2010;American journal of human genetics;86;138-47; 20137778
  • Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3.;Dong Shuo, Leung Keith K H, Pelling Anna L, Lee Patrick Y T, Tang Anna S P, Heng Henry H Q, Tsui Lap C, Tease Charles, Fisher Graham, Steel Karen P, Cheah Kathryn S E, ;2002;Genomics;79;777-84; 12036291
  • Sox2 is required for sensory organ development in the mammalian inner ear.;Kiernan Amy E, Pelling Anna L, Leung Keith K H, Tang Anna S P, Bell Donald M, Tease Charles, Lovell-Badge Robin, Steel Karen P, Cheah Kathryn S E, ;2005;Nature;434;1031-5; 15846349
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal brain morphology / IMPC
  • abnormal optic disk morphology / IMPC
  • irregularly shaped pupil / IMPC
  • developmental dysplasia / IMPC
  • embryonic growth retardation / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • atrophy / IMPC
  • enhanced contextual conditioning behavior / IMPC
MGI phenotypes (allele matching)
  • circling / MGI
  • head bobbing / MGI
  • abnormal sensory capabilities/reflexes/nociception / MGI
  • yellow coat color / MGI
  • absent cochlear nerve compound action potential / MGI
  • abnormal sulcus ampullaris morphology / MGI
  • deafness / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal inner ear morphology / MGI
  • abnormal awl hair morphology / MGI
  • abnormal zigzag hair morphology / MGI
  • abnormal auchene hair morphology / MGI
  • abnormal pinna reflex / MGI
  • impaired swimming / MGI
  • impaired righting response / MGI
  • abnormal placing response / MGI
  • abnormal cochlear hair cell morphology / MGI
  • decreased cochlear coiling / MGI
  • absent vestibular hair cells / MGI
  • decreased cochlear nerve compound action potential / MGI
  • dilated cochlea / MGI
  • head tossing / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal sulcus ampullaris morphology / MGI
  • diluted coat color / MGI
  • abnormal guard hair morphology / MGI
  • abnormal awl hair morphology / MGI
  • abnormal zigzag hair morphology / MGI
  • abnormal auchene hair morphology / MGI
  • abnormal esophagus morphology / MGI
  • abnormal esophageal squamous epithelium morphology / MGI
  • abnormal stomach morphology / MGI
  • abnormal salivary gland morphology / MGI
  • abnormal pituitary gland morphology / MGI
  • abnormal tongue morphology / MGI
  • decreased corpus callosum size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal thalamus morphology / MGI
  • motor neuron degeneration / MGI
  • nonconvulsive seizures / MGI
  • small testis / MGI
  • decreased body size / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • disorganized retinal layers / MGI
  • retina hyperplasia / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • head bobbing / MGI
  • abnormal pinna reflex / MGI
  • impaired swimming / MGI
  • impaired righting response / MGI
  • abnormal placing response / MGI
  • abnormal digestive system physiology / MGI
  • abnormal ectoderm development / MGI
  • absent egg cylinders / MGI
  • absent ectoplacental cone / MGI
  • edema / MGI
  • stomach inflammation / MGI
  • reduced male fertility / MGI
  • respiratory distress / MGI
  • deafness / MGI
  • abnormal sensory capabilities/reflexes/nociception / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal cochlear hair cell morphology / MGI
  • abnormal ependyma morphology / MGI
  • oligozoospermia / MGI
  • no phenotypic analysis / MGI
  • yellow coat color / MGI
  • decreased cochlear coiling / MGI
  • esophageal atresia / MGI
  • gastrointestinal ulcer / MGI
  • tracheoesophageal fistula / MGI
  • abnormal nervous system morphology / MGI
  • abnormal nervous system physiology / MGI
  • abnormal palate morphology / MGI
  • small vestibular saccule / MGI
  • absent vestibular hair cells / MGI
  • small utricle / MGI
  • absent cochlear hair cells / MGI
  • absent cochlear nerve compound action potential / MGI
  • decreased cochlear nerve compound action potential / MGI
  • dilated cochlea / MGI
  • decreased male germ cell number / MGI
  • decreased adrenocorticotropin level / MGI
  • decreased luteinizing hormone level / MGI
  • decreased thyroid-stimulating hormone level / MGI
  • decreased growth hormone level / MGI
  • decreased prolactin level / MGI
  • head tossing / MGI
  • dystonia / MGI
  • growth/size/body region phenotype / MGI
  • embryo phenotype / MGI
  • digestive/alimentary phenotype / MGI
  • behavior/neurological phenotype / MGI
  • respiratory system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal vestibular saccule morphology / MGI
  • optic nerve hypoplasia / MGI
  • abnormal fungiform papillae morphology / MGI
  • small adenohypophysis / MGI
  • decreased somatotroph cell number / MGI
  • enlarged lateral ventricles / MGI
  • enlarged third ventricle / MGI
  • increased trophoblast giant cell number / MGI
  • absent palatine gland / MGI
  • absent anterior lingual gland / MGI
  • abnormal neuron differentiation / MGI
  • abnormal epiglottis morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • embryonic lethality between implantation and placentation, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • absent embryonic epiblast / MGI
  • abnormal adenohypophysis development / MGI
  • bifurcated Rathke's pouch / MGI
  • tongue inflammation / MGI
  • abnormal Ebner's gland morphology / MGI

Literature references

  • Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.;Schraders Margit, Lee Kwanghyuk, Oostrik Jaap, Huygen Patrick L M, Ali Ghazanfar, Hoefsloot Lies H, Veltman Joris A, Cremers Frans P M, Basit Sulman, Ansar Muhammad, Cremers Cor W R J, Kunst Henricus P M, Ahmad Wasim, Admiraal Ronald J C, Leal Suzanne M, Kremer Hannie, ;2010;American journal of human genetics;86;138-47; 20137778
  • Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3.;Dong Shuo, Leung Keith K H, Pelling Anna L, Lee Patrick Y T, Tang Anna S P, Heng Henry H Q, Tsui Lap C, Tease Charles, Fisher Graham, Steel Karen P, Cheah Kathryn S E, ;2002;Genomics;79;777-84; 12036291
  • Sox2 is required for sensory organ development in the mammalian inner ear.;Kiernan Amy E, Pelling Anna L, Leung Keith K H, Tang Anna S P, Bell Donald M, Tease Charles, Lovell-Badge Robin, Steel Karen P, Cheah Kathryn S E, ;2005;Nature;434;1031-5; 15846349

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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