MGI phenotypes (allele matching)
CBACa;129P2-Git2Gt(XG510)Byg/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:05019 |
| Citation information | RRID:IMSR_EM:05019 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CBACa;129P2-Git2Gt(XG510)Byg/WtsiCnbc |
| Alternative name | Git2 genetrap |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Git2Gt(XG510)Byg |
| Gene/Transgene symbol | Git2 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | A genetrap from BayGenomics in the Git2 gene. |
| Phenotypic information | Brain anomalies, some clinical chemistry and haematology anomalies, poor breeders, but otherwise normal. See: http://www.sanger.ac.uk/mouseportal/pheno_overview.xls |
| Breeding history | Chimaeras from the 129P2 ES cells were mated with CBA/Ca and the colony was then maintained by intercrossing. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
MGI phenotypes (gene matching)
- extramedullary hematopoiesis / MGI
- enlarged spleen / MGI
- lung inflammation / MGI
- increased thermal nociceptive threshold / MGI
- no abnormal phenotype detected / MGI
- abnormal lung compliance / MGI
- abnormal neutrophil differentiation / MGI
- abnormal neutrophil physiology / MGI
- increased susceptibility to fungal infection / MGI
- decreased marginal zone B cell number / MGI
- impaired neutrophil chemotaxis / MGI
Literature references
- Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131