C3HeB/FeJ-Ostm1om/IegWtsiCnbc

Status

Available to order

EMMA IDEM:05048
Citation informationRRID:IMSR_EM:05048 

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International strain nameC3HeB/FeJ-Ostm1om/IegWtsiCnbc
Alternative nameOmi
Strain typeSpontaneous
Allele/Transgene symbolOstm1om
Gene/Transgene symbolOstm1

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Genetic informationOmi arose in a line that had previously been exposed to ENU but its origin is unknown. The mutation has not been found, but it maps to the region of Ostm1 and fails to complement grey-lethal.
Phenotypic informationOmi homozygotes show progressive loss of teeth from weaning onwards.
Breeding historyOriginated from mice derived from an ENU mutagenesis programme at GSF/IEG, Munich on a C3HeB/FeJ background and maintained on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.;Kiernan A E, Zalzman M, Fuchs H, Hrabe de Angelis M, Balling R, Steel K P, Avraham K B, ;1999;Journal of neurocytology;28;969-85; 10900098
  • A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.;Hertzano Ronna, Shalit Ella, Rzadzinska Agnieszka K, Dror Amiel A, Song Lin, Ron Uri, Tan Joshua T, Shitrit Alina Starovolsky, Fuchs Helmut, Hasson Tama, Ben-Tal Nir, Sweeney H Lee, de Angelis Martin Hrabe, Steel Karen P, Avraham Karen B, ;2008;PLoS genetics;4;e1000207; 18833301
  • Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1.;Bosman Erika A, Estabel Jeanne, Ismail Ozama, Podrini Christine, White Jacqueline K, Steel Karen P, ;2013;Mammalian genome : official journal of the International Mammalian Genome Society;24;44-53; 23160729
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent incisors / MGI
  • abnormal coat/hair pigmentation / MGI
  • premature death / MGI
  • decreased bone mineral density / MGI
  • osteopetrosis / MGI
  • failure of tooth eruption / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal rib morphology / MGI
  • decreased circulating LDL cholesterol level / MGI
  • abnormal maxilla morphology / MGI
  • abnormal femur morphology / MGI
  • decreased body size / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal molar morphology / MGI
  • decreased hemoglobin content / MGI
  • increased circulating alkaline phosphatase level / MGI
  • short femur / MGI
  • abnormal long bone morphology / MGI
  • abnormal compact bone morphology / MGI
  • decreased lean body mass / MGI
  • abnormal deltoid tuberosity morphology / MGI
  • short incisors / MGI
  • abnormal incisor morphology / MGI
  • decreased total body fat amount / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • abnormal maxillary zygomatic process morphology / MGI
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • failure of bone resorption / MGI
  • osteopetrosis / MGI
  • failure of tooth eruption / MGI
  • absent incisors / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal rib morphology / MGI
  • decreased circulating LDL cholesterol level / MGI
  • short snout / MGI
  • abnormal maxilla morphology / MGI
  • abnormal femur morphology / MGI
  • decreased body size / MGI
  • delayed eyelid opening / MGI
  • abnormal gait / MGI
  • eye inflammation / MGI
  • abnormal coat/hair pigmentation / MGI
  • premature death / MGI
  • abnormal skeleton development / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal molar morphology / MGI
  • decreased hemoglobin content / MGI
  • increased circulating alkaline phosphatase level / MGI
  • short femur / MGI
  • abnormal long bone morphology / MGI
  • abnormal compact bone morphology / MGI
  • abnormal molar crown morphology / MGI
  • decreased lean body mass / MGI
  • abnormal deltoid tuberosity morphology / MGI
  • short incisors / MGI
  • cachexia / MGI
  • abnormal incisor morphology / MGI
  • homeostasis/metabolism phenotype / MGI
  • failure of bone ossification / MGI
  • decreased total body fat amount / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • short lower incisors / MGI
  • abnormal mental foramen morphology / MGI
  • abnormal maxillary zygomatic process morphology / MGI
  • abnormal dentin mineralization / MGI
  • abnormal molar root morphology / MGI

Literature references

  • Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.;Kiernan A E, Zalzman M, Fuchs H, Hrabe de Angelis M, Balling R, Steel K P, Avraham K B, ;1999;Journal of neurocytology;28;969-85; 10900098
  • A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.;Hertzano Ronna, Shalit Ella, Rzadzinska Agnieszka K, Dror Amiel A, Song Lin, Ron Uri, Tan Joshua T, Shitrit Alina Starovolsky, Fuchs Helmut, Hasson Tama, Ben-Tal Nir, Sweeney H Lee, de Angelis Martin Hrabe, Steel Karen P, Avraham Karen B, ;2008;PLoS genetics;4;e1000207; 18833301
  • Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1.;Bosman Erika A, Estabel Jeanne, Ismail Ozama, Podrini Christine, White Jacqueline K, Steel Karen P, ;2013;Mammalian genome : official journal of the International Mammalian Genome Society;24;44-53; 23160729

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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