IMPC phenotypes (gene matching)
- prolonged RR interval / IMPC
B6.129S4-PoliGt(S15-7G1)Sor/Orl
| Status | Available to order |
| EMMA ID | EM:05107 |
| Citation information | RRID:IMSR_EM:05107 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S4-PoliGt(S15-7G1)Sor/Orl |
| Alternative name | DNA polymersase iota KO |
| Strain type | Gene-trap |
| Allele/Transgene symbol | PoliGt(S15-7G1)Sor |
| Gene/Transgene symbol | Poli |
Information from provider
| Provider | Claude-Agnes Reynaud |
| Provider affiliation | Faculte de Medecine Paris Descartes - Site Broussais, Unite INSERM 783 "Developpement du systeme immunitaire" |
| Genetic information | The gene-trap vector (Rosafary) was introduced between exons 1 and 2 in the ES cells. |
| Phenotypic information | Increased incidence of UV-induced mortality in cells which additionally lack the polymerase eta gene (Aoufouchi et al., Mol Cell Biol. 2015). |
| Breeding history | The heterozygotes obtained by breeding chimeras with C57BL/6 mice were crossed together. Inbred mice were backcrossed with C57BL/6 for at least 5 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- neoplasm / MGI
Literature references
- Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.;Gueranger Quentin, Stary Anne, Aoufouchi Saïd, Faili Ahmad, Sarasin Alain, Reynaud Claude-Agnès, Weill Jean-Claude, ;2008;DNA repair;7;1551-62; 18586118
- 129-Derived Mouse Strains Express an Unstable but Catalytically Active DNA Polymerase Iota Variant.;Aoufouchi Said, De Smet Annie, Delbos Frédéric, Gelot Camille, Guerrera Ida Chiara, Weill Jean-Claude, Reynaud Claude-Agnès, ;2015;Molecular and cellular biology;35;3059-70; 26124279