FVB-Tg(MMTV-ERBB2*)#Arbs/Cnbc
| Status | Available to order |
| EMMA ID | EM:05152 |
| Citation information | RRID:IMSR_EM:05152 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB-Tg(MMTV-ERBB2*)#Arbs/Cnbc |
| Alternative name | FVB HER2M687 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(MMTV-ERBB2*)#Arbs |
| Gene/Transgene symbol | Tg(MMTV-ERBB2*)#Arbs |
Information from provider
| Provider | Joaquín Arribas |
| Provider affiliation | Oncologia, Vall d'Hebron Institute d' Oncologia (VHIO) |
| Genetic information | Overexpression of Erbb2 gene variant 687. Isoform that encodes a C-terminal variant from Met 687. |
| Phenotypic information | Overexpression of Erbb2 gene variant 687 did not produce phenotypical alterations. |
| Breeding history | The FVB founder was outcrossed with FVB animals. The colony has been maintained outcrossing with FVB animals and inbreeding for more than 50 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous FVB/N males, wild-type FVB/N females |
| Stage of embryos | 8-cell |
Literature references
- A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis.;Pedersen Kim, Angelini Pier-Davide, Laos Sirle, Bach-Faig Alba, Cunningham Matthew P, Ferrer-Ramón Cristina, Luque-García Antonio, García-Castillo Jesús, Parra-Palau Josep Lluis, Scaltriti Maurizio, Ramón y Cajal Santiago, Baselga José, Arribas Joaquín, ;2009;Molecular and cellular biology;29;3319-31; 19364815